Evidence map›Paper›PMID 27459067›Full record

ReviewDevelopmental cell2016

The Dynamics of Apoptotic Cell Clearance.

Michael R Elliott, Kodi S Ravichandran

Abstract readReview
In one paragraph

Review in Developmental cell, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 202 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
202citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

202 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  19. Efferocytosis: The Silent Guardian of Tissue Homeostasis and Cardiovascular Health.Journal of cardiovascular development and disease · 2025
    Review
  20. Article

142 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Michael R ElliottDepartment of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA; David H. Smith Center for Vaccine Biology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA. Electronic address: michael_elliott@urmc.rochester.edu.
Kodi S RavichandranDepartment of Microbiology, Immunology, Cancer Biology, University of Virginia, Charlottesville, VA 22908, USA; Beirne B. Carter Center for Immunology Research, University of Virginia, Charlottesville, VA 22908, USA; Center for Cell Clearance, University of Virginia, Charlottesville, VA 22908, USA. Electronic address: ravi@virginia.edu.

Funding

Role of Pannexins in Vascular Smooth Muscle CellsP01HL120840 · NHLBI · UNIVERSITY OF VIRGINIA · PI BAYLISS, DOUGLAS A., RAVICHANDRAN, KODI S · 2014 to 2023
$24.0M
Role of ELMO and DOCK 180 in signaling to engulfmentR01GM064709 · NIGMS · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI LORENZ, ULRIKE, RAVICHANDRAN, KODI S · 2003 to 2016
$3.6M
Immunoregulatory role of CD73 in efferocytosisR01AI114554 · NIAID · UNIVERSITY OF VIRGINIA · PI ELLIOTT, MICHAEL RUSTY · 2015 to 2019
$2.5M
Cell Clearance in Urogenital TractR01HD074981 · NICHD · UNIVERSITY OF VIRGINIA · PI LYSIAK, JEFFREY J, RAVICHANDRAN, KODI S · 2013 to 2017
$1.6M
Release of find-me signals during apoptotic cell clearanceR01GM107848 · NIGMS · UNIVERSITY OF VIRGINIA · PI BAYLISS, DOUGLAS A., RAVICHANDRAN, KODI S · 2013 to 2016
$1.2M
NHLBI NIH HHS P01 HL120840NIAID NIH HHS R01 AI114554NICHD NIH HHS R01 HD074981NIGMS NIH HHS R01 GM064709NIGMS NIH HHS R01 GM107848
6 · The paper itself

Abstract

The phagocytic clearance of dying cells in a tissue is a highly orchestrated series of intercellular events coordinated by a complex signaling network. Recent data from genetic, biochemical, and live-imaging approaches have greatly enhanced our understanding of the dynamics of cell clearance and how the process is orchestrated at the cellular and tissue levels. We discuss how networks regulating apoptotic cell clearance are integrated to enable a rapid, efficient, and high-capacity clearance system within tissues.

Indexed as

ApoptosisAnimalsHumansPhagocytosisSignal Transductionapoptosischemotaxisefferocytosisimagingimmunityphagocytosissignal transduction

Identifiers

PMID27459067
PMCPMC4966906

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.