Evidence map›Paper›PMID 27458823›Full record

ArticleJournal of magnetic resonance imaging : JMRI2017

Optimal configuration of respiratory navigator gating for the quantification of left ventricular strain using spiral cine displacement encoding with stimulated echoes (DENSE) MRI.

Sean M Hamlet, Christopher M Haggerty, Jonathan D Suever, Gregory J Wehner, Kristin N Andres, David K Powell, Xiaodong Zhong, Brandon K Fornwalt

Abstract read
In one paragraph

Article in Journal of magnetic resonance imaging : JMRI, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. An interactive videogame designed to improve respiratory navigator efficiency in children undergoing cardiovascular magnetic resonance.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2016
    Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sean M HamletDepartment of Electrical and Computer Engineering, University of Kentucky, Lexington, Kentucky, USA.
Christopher M HaggertyDepartment of Pediatrics, University of Kentucky, Lexington, KY, USA.
Jonathan D SueverDepartment of Pediatrics, University of Kentucky, Lexington, KY, USA.
Gregory J WehnerDepartment of Pediatrics, University of Kentucky, Lexington, KY, USA.
Kristin N AndresDepartment of Pediatrics, University of Kentucky, Lexington, KY, USA.
David K PowellDepartment of Biomedical Engineering, University of Kentucky, Lexington, Kentucky, USA.
Xiaodong ZhongMR R&D Collaborations, Siemens Healthcare, Atlanta, GA, USA.
Brandon K FornwaltDepartment of Pediatrics, University of Kentucky, Lexington, KY, USA.

Funding

Kentucky Center for Clinical and Translational ScienceUL1TR001998 · NCATS · UNIVERSITY OF KENTUCKY · PI HARTMANN, KATHERINE E, KERN, PHILIP A · 2016 to 2025
$34.2M
The role of IKKß in linking obesity to adipose tissue inflammation and adipogeneP20GM103527 · NIGMS · UNIVERSITY OF KENTUCKY · PI MORRIS, ANDREW J · 2012 to 2017
$13.7M
Kentucky Center for Clinical and Translational ScienceUL1TR000117 · NCATS · UNIVERSITY OF KENTUCKY · PI KERN, PHILIP A · 2012 to 2015
$13.3M
Exploring the Role of Dyssynchrony in Pediatric Heart Disease with MRIDP5OD012132 · OD · UNIVERSITY OF KENTUCKY · PI FORNWALT, BRANDON K · 2012 to 2016
$2.2M
Bringing Advanced Heart MRI to Pediatric Clinics Using an Interactive VideogameF31HL126403 · NHLBI · UNIVERSITY OF KENTUCKY · PI HAMLET, SEAN MICHAEL · 2015 to 2017
$68k
NCATS NIH HHS UL1 TR000117NCATS NIH HHS UL1 TR001998NHLBI NIH HHS F31 HL126403NIGMS NIH HHS P20 GM103527NIH HHS DP5 OD012132
6 · The paper itself

Abstract

purposeTo determine the optimal respiratory navigator gating configuration for the quantification of left ventricular strain using spiral cine displacement encoding with stimulated echoes (DENSE) MRI. MATERIALS AND

methodsTwo-dimensional spiral cine DENSE was performed on a 3 Tesla MRI using two single-navigator configurations (retrospective, prospective) and a combined "dual-navigator" configuration in 10 healthy adults and 20 healthy children. The adults also underwent breathhold DENSE as a reference standard for comparisons. Peak left ventricular strains, signal-to-noise ratio (SNR), and navigator efficiency were compared. Subjects also underwent dual-navigator gating with and without visual feedback to determine the effect on navigator efficiency.

resultsThere were no differences in circumferential, radial, and longitudinal strains between navigator-gated and breathhold DENSE (P = 0.09-0.95) (as confidence intervals, retrospective: [-1.0%-1.1%], [-7.4%-2.0%], [-1.0%-1.2%]; prospective: [-0.6%-2.7%], [-2.8%-8.3%], [-0.3%-2.9%]; dual: [-1.6%-0.5%], [-8.3%-3.2%], [-0.8%-1.9%], respectively). The dual configuration maintained SNR compared with breathhold acquisitions (16 versus 18, P = 0.06). SNR for the prospective configuration was lower than for the dual navigator in adults (P = 0.004) and children (P < 0.001). Navigator efficiency was higher (P < 0.001) for both retrospective (54%) and prospective (56%) configurations compared with the dual configuration (35%). Visual feedback improved the dual configuration navigator efficiency to 55% (P < 0.001).

conclusionWhen quantifying left ventricular strains using spiral cine DENSE MRI, a dual navigator configuration results in the highest SNR in adults and children. In adults, a retrospective configuration has good navigator efficiency without a substantial drop in SNR. Prospective gating should be avoided because it has the lowest SNR. Visual feedback represents an effective option to maintain navigator efficiency while using a dual navigator configuration. LEVEL OF EVIDENCE: 2 J. Magn. Reson. Imaging 2017;45:786-794.

Indexed as

Signal Processing, Computer-AssistedAdolescentCardiac-Gated Imaging TechniquesElasticity Imaging TechniquesElastic ModulusFemaleHeart VentriclesHumansImage EnhancementMagnetic Resonance Imaging, CineMaleReproducibility of ResultsSensitivity and SpecificityStress, MechanicalTensile StrengthVentricular Function, LeftbreathholdsDENSEnavigator efficiencyrespiratory navigatorsignal-to-noise ratiostrain

Identifiers

PMID27458823
PMCPMC5269554

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.