ArticleGastroenterology and hepatology from bed to bench2016
Development of systemic sclerosis in patients with autoimmune hepatitis: an emerging overlap syndrome.
Article in Gastroenterology and hepatology from bed to bench, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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Who cites it
11 citing papers in PubMed, 18 citations in OpenAlex.
- First, paradigmatic case of AMA-negative primary biliary cholangiitis with rods and rings autoantibodies: report of future implications.Gastroenterology and hepatology from bed to bench · 2025Article
- Incidence and Predictors of an Abnormal Liver Function Test Among 674 Systemic Sclerosis Patients: A Cohort Study.Open access rheumatology : research and reviews · 2023Article
- Autoimmune liver diseases in systemic rheumatic diseases.World journal of gastroenterology · 2022Review
- Systemic Sclerosis and the Liver.Clinical liver disease · 2021Review
- Acute severe autoimmune hepatitis with anti-rods and rings autoantibodies; literature first evidence.Gastroenterology and hepatology from bed to bench · 2021Article
- Autoimmune Hepatitis and Systemic Sclerosis: a Rare Association.European journal of case reports in internal medicine · 2019Article
- Primary biliary cholangitis with contemporary presence of anti-mithocondrial and anti-rods and rings autoantibodies: literature first case.Gastroenterology and hepatology from bed to bench · 2019Article
- Gastrointestinal and Hepatic Disease in Systemic Sclerosis.Rheumatic diseases clinics of North America · 2018Review
- Gastrointestinal Manifestations of Systemic Sclerosis.Rheumatology (Sunnyvale, Calif.) · 2018Article
- Review article: pathogenesis and clinical manifestations of gastrointestinal involvement in systemic sclerosis.Alimentary pharmacology & therapeutics · 2017Review
- Development of PBC/SSc overlap syndrome in chronic GVHD patient: immunological implications in the presence of mitochondrial, nucleolar and spindle midzone autoantigens.Gastroenterology and hepatology from bed to bench · 2017Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimWe described two case reports of AIH/SSc overlap syndrome and reviewed literatures regarding this issue.
backgroundAIH is a chronic hepatitis of unknown aetiology characterized by continuing hepatocellular necrosis and inflammation. AIH overlap syndromes have been reported with other autoimmune diseases. PATIENTS AND
methodsAccording to the classification criteria for SSc, we conducted a retrospective chart review of 35 cases with biopsy-proven AIH over the past 5 years at our institution. We reviewed the MEDLINE database using the appropriate key-words.
resultsA chart review of 35 cases (M/F ratio 1:2, mean age 47.6±10.3 years) revealed nine patients (9/35, 25.7%) with CTD (four males and three females with a mean age of 45.1±8.4 years). All patients had ANA. Four patients were SSA/Ro positive UCTD (1/35, 2.85%), and six patients developed SLE (6/35, 17.1%). Only two female patients (2/35, 5.7%) with specific SSc AAb developed a systemic sclerosis. We described a patient with AIH who was diagnosed with diffuse systemic sclerosis-sine scleroderma with positive anti-centromere B and SSA/Ro52 KDa antibodies. We also reported a patient with AIH who was diagnosed limited SSc with contemporary presence of anti-centromere A and anti-RNA polymerase III antibody.
conclusionWe suggest that SSc may be considered to be one of the manifestations associated with AIH. Patients with AIH may have an increased risk to develop SSc and should be followed, especially when Raynaud phenomenon was found.
Indexed as
Identifiers
27458514PMC4947136W2464162198What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.