Evidence map›Paper›PMID 27458455›Full record

ArticleFrontiers in microbiology2016

Pathogenesis and Phylogenetic Analyses of Two Avian Influenza H7N1 Viruses Isolated from Wild Birds.

Hongmei Jin, Deli Wang, Jing Sun, Yanfang Cui, Guang Chen, Xiaolin Zhang, Jiajie Zhang, Xiang Li, Hongliang Chai, Yuwei Gao and 2 more

Abstract read
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Article in Frontiers in microbiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Hongmei JinCollege of Wildlife Resources, Northeast Forestry University Harbin, China.
Deli WangHarbin Veterinary Research Institute, Chinese Academy of Agriculture Sciences Harbin, China.
Jing SunCollege of Wildlife Resources, Northeast Forestry UniversityHarbin, China; Research Institute of Forestry Ecology, Environment and ProtectionBeijing, China.
Yanfang CuiHarbin Veterinary Research Institute, Chinese Academy of Agriculture Sciences Harbin, China.
Guang ChenCollege of Wildlife Resources, Northeast Forestry UniversityHarbin, China; Hubei Province Wildlife Epidemic Disease CenterWuhan, China.
Xiaolin ZhangCollege of Wildlife Resources, Northeast Forestry University Harbin, China.
Jiajie ZhangCollege of Wildlife Resources, Northeast Forestry University Harbin, China.
Xiang LiCollege of Wildlife Resources, Northeast Forestry University Harbin, China.
Hongliang ChaiCollege of Wildlife Resources, Northeast Forestry University Harbin, China.
Yuwei GaoChangchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences Changchun, China.
Yanbing LiHarbin Veterinary Research Institute, Chinese Academy of Agriculture Sciences Harbin, China.
Yuping HuaCollege of Wildlife Resources, Northeast Forestry University Harbin, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The emergence of human infections with a novel H7N9 influenza strain has raised global concerns about a potential human pandemic. To further understand the character of other influenza viruses of the H7 subtype, we selected two H7N1 avian influenza viruses (AIVs) isolated from wild birds during routine surveillance in China: A/Baer's Pochard/Hunan/414/2010 (BP/HuN/414/10) (H7N1) and A/Common Pochard/Xianghai/420/2010 (CP/XH/420/10) (H7N1). To better understand the molecular characteristics of these two isolated H7N1 viruses, we sequenced and phylogenetically analyzed their entire genomes. The results showed that the two H7N1 strains belonged to a Eurasian branch, originating from a common ancestor. Phylogenetic analysis of their hemagglutinin (HA) genes showed that BP/HuN/414/10 and CP/XH/420/10 have a more distant genetic relationship with A/Shanghai/13/2013 (H7N9), with similarities of 91.6 and 91.4%, respectively. To assess the replication and pathogenicity of these viruses in different hosts, they were inoculated in chickens, ducks and mice. Although, both CP/XH/420/10 and BP/HuN/414/10 can infect chickens, ducks and mice, they exhibited different replication capacities in these animals. The results of this study demonstrated that two low pathogenic avian influenza (LPAI) H7N1 viruses of the Eurasian branch could infect mammals and may even have the potential to infect humans. Therefore, it is important to monitor H7 viruses in both domestic and wild birds.

Indexed as

Avian influenza virusH7N1H7N9pathogenic analysesphylogenetic analysis

Identifiers

PMID27458455
PMCPMC4935687

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.