ArticleFrontiers in pharmacology2016
Anti-nociceptive Activity of Ethnomedicinally Important Analgesic Plant Isodon rugosus Wall. ex Benth: Mechanistic Study and Identifications of Bioactive Compounds.
Article in Frontiers in pharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
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- Investigation of Analgesic, Anti-Inflammatory, and Thrombolytic Effects of Methanolic Extract and Its Fractions ofMolecules (Basel, Switzerland) · 2025Article
- Evaluation of the Therapeutic Potential of the Methanolic Extract and Fractions ofCurrent pharmaceutical design · 2025Article
- The neurobiology of plant-based therapeutics in women's reproductive health: mechanisms, efficacy, and clinical translation.Frontiers in nutrition · 2025Review
- Investigation of anti-nociceptive, anti-inflammatory potential and ADMET studies of pure compounds isolated fromFrontiers in pharmacology · 2024Article
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- Evaluation ofHeliyon · 2023Article
- GC-MS Analysis and Various In Vitro and In Vivo Pharmacological Potential ofEvidence-based complementary and alternative medicine : eCAM · 2022Article
- Antioxidant, Enzyme Inhibitory, and Molecular Docking Approaches to the Antidiabetic Potentials of Bioactive Compounds fromEvidence-based complementary and alternative medicine : eCAM · 2022Article
- Analagesic and Anti-Inflammatory Potentials of a Less Ulcerogenic Thiadiazinethione Derivative in Animal Models: Biochemical and Histochemical Correlates.Drug design, development and therapy · 2022Article
- Phytochemical screening and antibacterial activity ofFrontiers in plant science · 2022Article
- Pharmacological activities and gas chromatography-mass spectrometry analysis for the identification of bioactive compounds fromFrontiers in pharmacology · 2022Article
- Synthesis of Michael Adducts as Key Building Blocks for Potential Analgesic Drugs: In vitro, in vivo and in silico Explorations.Drug design, development and therapy · 2021Article
- Methanol, ethyl acetate and n-hexane extracts ofHeliyon · 2021Article
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- Traditional knowledge on herbal drinks among indigenous communities in Azad Jammu and Kashmir, Pakistan.Journal of ethnobiology and ethnomedicine · 2018Article
- Chemical Characterization, Analgesic, Antioxidant, and Anticholinesterase Potentials of Essential Oils FromFrontiers in pharmacology · 2018Article
- Anti-nociceptive effect of stigmasterol in mouse models of acute and chronic pain.Naunyn-Schmiedeberg's archives of pharmacology · 2017Article
- Demonstration of biological activities of extracts from Isodon rugosus Wall. Ex Benth: Separation and identification of bioactive phytoconstituents by GC-MS analysis in the ethyl acetate extract.BMC complementary and alternative medicine · 2017Article
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5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Isodon rugosus Wall. ex Benth. is extensively used as traditional medicine for the management of various types of pain including tooth ache, gastric pain, abdominal pain, ear ache, and generalized body pain. The current study is designed to scientifically verify the purported uses of I. rugosus as analgesic agent and to figure out its possible mechanism of action. Bioactive compounds responsible for analgesic activity were identified using GC and GC-MS analysis. Analgesic potentials were evaluated using acetic acid induced writhing, hot plate test, and formalin induced paw licking test. In acetic acid induced writhing chloroform fraction (Ir.Chf) exhibited 53% analgesia while formalin test displayed 61% inhibition at phase-I and 45% at phase-II respectively at a dose of 100 mg/kg. Similarly, in hot plate test Ir.Chf displayed average reaction time of 7 min at 15, 30, 45, and 60 min intervals. The possible mechanism of action was found to be the central pathway via opioidergic receptors as the mice showed morphine like analgesic activity at pre-administration of naloxone (opioid antagonist) in hot plate and formalin tests. In GC-MS analysis, 83 compounds were identified among which eight compounds including benzyl alcohol, sebacic acid, myristic acid, phytol, sugiol, Tocopherol, α-Amyrin, and stigmasterol were sorted out as previously reported analgesic compounds. Current study revealed that analgesic potential of I. rugosus can attributed to the presence of analgesic compounds. It may also be concluded that opioids receptors are involved in the analgesic mechanism of I. rugosus due to effective antagonism of nalaxone.
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