ArticleFrontiers in aging neuroscience2016
Disrupted Brain Functional Network Architecture in Chronic Tinnitus Patients.
Article in Frontiers in aging neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A Multimodal Meta-Analysis of Structural and Functional Changes in the Brain of Tinnitus.Frontiers in human neuroscience · 2020Pooled it
- Dehydration-associated cerebral hypoperfusion in sudden sensorineural hearing loss: an arterial spin labeling-based preliminary study.Frontiers in neurology · 2025Article
- Amygdala structural and functional reorganization as an indicator of affective dysfunction in patients with tinnitus.Human brain mapping · 2024Article
- Glymphatic system dysfunction associated with cognitive impairment in chronic tinnitus patients.Frontiers in neuroscience · 2024Article
- [Electroencephalographic microstates in vestibular schwannoma patients with tinnitus].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2023Article
- Study on tinnitus-related electroencephalogram microstates in patients with vestibular schwannomas.Frontiers in neuroscience · 2023Article
- EEG spectral and microstate analysis originating residual inhibition of tinnitus induced by tailor-made notched music training.Frontiers in neuroscience · 2023Article
- Role of insula and its subregions in progression from recent onset to chronic idiopathic tinnitus.Brain communications · 2023Article
- Altered Cerebro-Cerebellar Effective Connectivity in New-Onset Juvenile Myoclonic Epilepsy.Brain sciences · 2022Article
- Resting-state Networks in Tinnitus : A Scoping Review.Clinical neuroradiology · 2022Article
- Aberrant functional and effective connectivity of the frontostriatal network in unilateral acute tinnitus patients with hearing loss.Brain imaging and behavior · 2022Article
- Analysis of cerebellum with magnetic resonance 3D T1 sequence in individuals with chronic subjective tinnitus.Acta neurologica Belgica · 2021Article
- Aberrant brain functional hubs and causal connectivity in presbycusis.Brain imaging and behavior · 2021Article
- Alterations of brain activity and functional connectivity in transition from acute to chronic tinnitus.Human brain mapping · 2021Article
- Acupuncture Treatment Decreased Temporal Variability of Dynamic Functional Connectivity in Chronic Tinnitus.Frontiers in neuroscience · 2021Article
- Cerebral Blood Flow Difference Between Acute and Chronic Tinnitus Perception: A Perfusion Functional Magnetic Resonance Imaging Study.Frontiers in neuroscience · 2021Article
- Reduced grey- and white matter volumes due to unilateral hearing loss following treatment for vestibular schwannoma.Heliyon · 2020Article
- Computer-Aided Tinnitus Detection based on Brain Network Analysis of EEG Functional Connectivity.Journal of biomedical physics & engineering · 2019Article
- Altered Functional Connectivity in Patients With Sloping Sensorineural Hearing Loss.Frontiers in human neuroscience · 2019Article
- Disrupted Intraregional Brain Activity and Functional Connectivity in Unilateral Acute Tinnitus Patients With Hearing Loss.Frontiers in neuroscience · 2019Article
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Authors and funding
7 authors.
Funding
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Abstract
purposeResting-state functional magnetic resonance imaging (fMRI) studies have demonstrated the disruptions of multiple brain networks in tinnitus patients. Nonetheless, several studies found no differences in network processing between tinnitus patients and healthy controls (HCs). Its neural bases are poorly understood. To identify aberrant brain network architecture involved in chronic tinnitus, we compared the resting-state fMRI (rs-fMRI) patterns of tinnitus patients and HCs. MATERIALS AND
methodsChronic tinnitus patients (n = 24) with normal hearing thresholds and age-, sex-, education- and hearing threshold-matched HCs (n = 22) participated in the current study and underwent the rs-fMRI scanning. We used degree centrality (DC) to investigate functional connectivity (FC) strength of the whole-brain network and Granger causality to analyze effective connectivity in order to explore directional aspects involved in tinnitus.
resultsCompared to HCs, we found significantly increased network centrality in bilateral superior frontal gyrus (SFG). Unidirectionally, the left SFG revealed increased effective connectivity to the left middle orbitofrontal cortex (OFC), left posterior lobe of cerebellum (PLC), left postcentral gyrus, and right middle occipital gyrus (MOG) while the right SFG exhibited enhanced effective connectivity to the right supplementary motor area (SMA). In addition, the effective connectivity from the bilateral SFG to the OFC and SMA showed positive correlations with tinnitus distress.
conclusionsRs-fMRI provides a new and novel method for identifying aberrant brain network architecture. Chronic tinnitus patients have disrupted FC strength and causal connectivity mostly in non-auditory regions, especially the prefrontal cortex (PFC). The current findings will provide a new perspective for understanding the neuropathophysiological mechanisms in chronic tinnitus.
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