Evidence map›Paper›PMID 27458360›Full record

ArticleFrontiers in human neuroscience2016

COMT Val(158)Met Polymorphism Is Associated with Verbal Working Memory in Neurofibromatosis Type 1.

Danielle de Souza Costa, Jonas J de Paula, Antonio M Alvim-Soares, Patrícia A Pereira, Leandro F Malloy-Diniz, Luiz O C Rodrigues, Marco A Romano-Silva, Débora M de Miranda

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in human neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Danielle de Souza CostaPostgraduate Program in Molecular Medicine, School of Medicine, Federal University of Minas Gerais Belo Horizonte, Brazil.
Jonas J de PaulaPostgraduate Program in Molecular Medicine, School of Medicine, Federal University of Minas GeraisBelo Horizonte, Brazil; Department of Psychology, Faculty of Medical Sciences of Minas GeraisBelo Horizonte, Brazil.
Antonio M Alvim-SoaresPostgraduate Program in Molecular Medicine, School of Medicine, Federal University of Minas Gerais Belo Horizonte, Brazil.
Patrícia A PereiraPostgraduate Program in Molecular Medicine, School of Medicine, Federal University of Minas Gerais Belo Horizonte, Brazil.
Leandro F Malloy-DinizDepartment of Psychiatry, School of Medicine, Federal University of Minas GeraisBelo Horizonte, Brazil; National Institute of Science and Technology of Molecular MedicineBelo Horizonte, Brazil.
Luiz O C RodriguesNeurofibromatosis Outpatient Reference Center, School of Medicine, Federal University of Minas Gerais Belo Horizonte, Brazil.
Marco A Romano-SilvaDepartment of Psychiatry, School of Medicine, Federal University of Minas GeraisBelo Horizonte, Brazil; National Institute of Science and Technology of Molecular MedicineBelo Horizonte, Brazil.
Débora M de MirandaNational Institute of Science and Technology of Molecular MedicineBelo Horizonte, Brazil; Department of Pediatrics, School of Medicine, Federal University of Minas GeraisBelo Horizonte, Brazil.
Universidade Federal de Minas Gerais · BRFaculdade de Ciências Médicas de Minas Gerais · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neurofibromatosis type I (NF1) is a neurogenetic disease marked by multiple cognitive and learning problems. Genetic variants may account for phenotypic variance in NF1. Here, we investigated the association between the catechol-O-methyltransferase (COMT) Val(158)Met polymorphism and working memory and arithmetic performance in 50 NF1 individuals. A significant association of the COMT polymorphism was observed only with verbal working memory, as measured by the backward digit-span task with an advantageous performance for Met/Met carriers. To study how genetic modifiers influence NF1 cognitive performance might be of importance to decrease the unpredictability of the cognitive profile among NF1 patients.

Indexed as

arithmeticCOMT Val158Met polymorphismexecutive functionsgenetic modifiersneurofibromatosis type Ineuropsychologyworking memory

Identifiers

PMID27458360
PMCPMC4932101
OpenAlexW2469907528

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.