Evidence map›Paper›PMID 27458239›Full record

ArticleEMBO reports2016

Structural role of the T94I rhodopsin mutation in congenital stationary night blindness.

Ankita Singhal, Ying Guo, Milos Matkovic, Gebhard Schertler, Xavier Deupi, Elsa Cy Yan, Joerg Standfuss

Open access · bronzeAbstract read
In one paragraph

Article in EMBO reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 40 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Whale shark rhodopsin adapted to deep-sea lifestyle by a substitution associated with human disease.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  7. Article
  8. Structural aspects of rod opsin and their implication in genetic diseases.Pflugers Archiv : European journal of physiology · 2021
    Review
  9. Review
  10. Article
  11. Dark noise and retinal degeneration from D190N-rhodopsin.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  12. Light Dynamics of the Retinal-Disease-Relevant G90D Bovine Rhodopsin Mutant.Angewandte Chemie (International ed. in English) · 2020
    Article
  13. Article
  14. Article
  15. Crystal structure of jumping spider rhodopsin-1 as a light sensitive GPCR.Proceedings of the National Academy of Sciences of the United States of America · 2019
    Article
  16. Article
  17. Article
  18. Article
  19. Convergent evolution of tertiary structure in rhodopsin visual proteins from vertebrates and box jellyfish.Proceedings of the National Academy of Sciences of the United States of America · 2018
    Article
  20. Ligand channel in pharmacologically stabilized rhodopsin.Proceedings of the National Academy of Sciences of the United States of America · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Ankita SinghalDivision of Biology and Chemistry, Laboratory of Biomolecular Research, Paul Scherrer Institute, Villigen, Switzerland.
Ying GuoDepartment of Chemistry, Yale University, New Haven, CT, USA.
Milos MatkovicDivision of Biology and Chemistry, Laboratory of Biomolecular Research, Paul Scherrer Institute, Villigen, Switzerland.
Gebhard SchertlerDivision of Biology and Chemistry, Laboratory of Biomolecular Research, Paul Scherrer Institute, Villigen, Switzerland Deparment of Biology, ETH Zurich, Zürich, Switzerland.
Xavier DeupiDivision of Biology and Chemistry, Laboratory of Biomolecular Research, Paul Scherrer Institute, Villigen, Switzerland Condensed Matter Theory Group, Paul Scherrer Institute, Villigen, Switzerland.
Elsa Cy YanDepartment of Chemistry, Yale University, New Haven, CT, USA.
Joerg StandfussDivision of Biology and Chemistry, Laboratory of Biomolecular Research, Paul Scherrer Institute, Villigen, Switzerland joerg.standfuss@psi.ch.ORCID 0000-0001-8825-386X
Paul Scherrer Institute · CHYale University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Congenital stationary night blindness (CSNB) is an inherited and non-progressive retinal dysfunction. Here, we present the crystal structure of CSNB-causing T94I

Indexed as

MutationBinding SitesCatalytic DomainDarknessEye Diseases, HereditaryGenetic Association StudiesGenetic Diseases, X-LinkedHumansModels, BiologicalModels, MolecularMyopiaNight BlindnessProtein BindingProtein ConformationProtein StabilityRhodopsinRhodopsinSchiff Basescongenital stationary night blindnessconstitutive activityG protein‐coupled receptorsrhodopsinvisual system

Identifiers

PMID27458239
PMCPMC5048376
OpenAlexW2487489013

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.