Evidence map›Paper›PMID 27458227›Full record

ArticleAntimicrobial agents and chemotherapy2016

The Antimicrobial Peptides P-113Du and P-113Tri Function against Candida albicans.

Guan-Yu Lin, Hsueh-Fen Chen, Yao-Peng Xue, Ying-Chieh Yeh, Chia-Lu Chen, Ming-Sun Liu, Wen-Chi Cheng, Chung-Yu Lan

Open access · bronzeAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Modifying Antifungal Peptides as Safe Food Preservatives.Journal of agricultural and food chemistry · 2025
    Article
  3. Synergic Effect of the Antimicrobial Peptide ToAP2 and Fluconazole onInternational journal of molecular sciences · 2024
    Article
  4. Article
  5. Review
  6. Antimicrobial Activity of the Peptide LfcinB15 againstJournal of fungi (Basel, Switzerland) · 2021
    Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Guan-Yu LinInstitute of Molecular and Cellular Biology, National Tsing Hua University, Hsinchu, Taiwan.
Hsueh-Fen ChenInstitute of Molecular and Cellular Biology, National Tsing Hua University, Hsinchu, Taiwan.
Yao-Peng XueDepartment of Life Science, National Tsing Hua University, Hsinchu, Taiwan.
Ying-Chieh YehInstitute of Molecular and Cellular Biology, National Tsing Hua University, Hsinchu, Taiwan.
Chia-Lu ChenInstitute of Molecular and Cellular Biology, National Tsing Hua University, Hsinchu, Taiwan.
Ming-Sun LiuGeneral Biologicals Corporation, Hsinchu, Taiwan.
Wen-Chi ChengGeneral Biologicals Corporation, Hsinchu, Taiwan wenchi.cheng@gbc.com.tw cylan@life.nthu.edu.tw.
Chung-Yu LanInstitute of Molecular and Cellular Biology, National Tsing Hua University, Hsinchu, Taiwan Department of Life Science, National Tsing Hua University, Hsinchu, Taiwan wenchi.cheng@gbc.com.tw cylan@life.nthu.edu.tw.
National Tsing Hua University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Two antimicrobial P-113 peptide derivatives, P-113Du and P-113Tri, were investigated in this study. Notably, P-113Du and P-113Tri contained significant fractions of α-helix conformation and were less sensitive to high salt and low pH than P-113. Moreover, compared to P-113, these peptides exhibited increased antifungal activity against planktonic cells, biofilm cells, and clinical isolates of Candida albicans and non-albicans Candida spp. These results suggest that P-113Du and P-113Tri are promising candidates for development as novel antifungal agents.

Indexed as

Antifungal AgentsAscorbic AcidBiofilmsCandida albicansDrug Evaluation, PreclinicalHistatinsHumansHydrogen-Ion ConcentrationMicrobial Sensitivity TestsPlanktonProtein ConformationAntifungal AgentsAscorbic AcidHistatinsP-113DP-113Tri

Identifiers

PMID27458227
PMCPMC5038333
OpenAlexW2499863882

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.