ArticleAntimicrobial agents and chemotherapy2016
Characterization of Spectinomycin Resistance in Streptococcus suis Leads to Two Novel Insights into Drug Resistance Formation and Dissemination Mechanism.
Article in Antimicrobial agents and chemotherapy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 35 citations in OpenAlex.
- Mutations in ribosomal protein uS5 alter translation fidelity and mutagenesis inJournal of bacteriology · 2025Article
- Recent development and fighting strategies for lincosamide antibiotic resistance.Clinical microbiology reviews · 2024Review
- Multiple Drug ResistantAntibiotics (Basel, Switzerland) · 2024Article
- Antibiotic Resistance Patterns and Molecular Characterization of Streptococcus suis Isolates from Swine and Humans in China.Microbiology spectrum · 2023Article
- Article
- Characterization of Streptococcus equi subsp. zooepidemicus isolates containing lnuB gene responsible for the L phenotype.PloS one · 2023Article
- Genomic characterization and virulence of Streptococcus suis serotype 4 clonal complex 94 recovered from human and swine samples.PloS one · 2023Article
- Genetic diversity and variation in antimicrobial-resistance determinants of non-serotype 2Microbial genomics · 2022Article
- Large-scale genomic analysis of antimicrobial resistance in the zoonotic pathogen Streptococcus suis.BMC biology · 2021Article
- Update on the Mechanisms of Antibiotic Resistance and the Mobile Resistome in the Emerging Zoonotic PathogenMicroorganisms · 2021Review
- Investigation of the Genomic and Pathogenic Features of the Potentially ZoonoticPathogens (Basel, Switzerland) · 2021Article
- Active Human and Porcine Serum Induce Competence for Genetic Transformation in the Emerging Zoonotic PathogenPathogens (Basel, Switzerland) · 2021Article
- Emergence of aFrontiers in veterinary science · 2021Article
- Horizontal Transfer of DifferentFrontiers in microbiology · 2021Article
- A Conjugative MDR pMG1-Like Plasmid Carrying theFrontiers in microbiology · 2021Article
- Chromosomal Conjugative and Mobilizable Elements inPathogens (Basel, Switzerland) · 2019Article
- Genomic Epidemiology ofPathogens (Basel, Switzerland) · 2019Article
- New genetic context ofAntimicrobial resistance and infection control · 2019Article
- Antimicrobial Resistance inMicrobiology spectrum · 2018Review
- Adaptation in toxic environments: comparative genomics of loci carrying antibiotic resistance genes derived from acid mine drainage waters.Environmental science and pollution research international · 2018Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Spectinomycin is an aminocyclitol antibiotic used clinically to treat a variety of infections in animals. Here, we characterized drug resistance prevalence in clinical Streptococcus suis isolates and discovered a novel resistance mechanism in which the s5 mutation (Gly26Asp) results in high spectinomycin resistance. Additionally, a novel integrative and conjugative element encompassing a multidrug resistance spw_like-aadE-lnu(B)-lsa(E) cluster and a cadmium resistance operon were identified, suggesting a possible cause for the wide dissemination of spectinomycin resistance in S. suis.
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