ArticleGut and liver2016
Impact of Long-Term Proton Pump Inhibitor Therapy on Gut Microbiota in F344 Rats: Pilot Study.
Article in Gut and liver, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- Association between proton pump inhibitor use and migraine: a systematic review and meta-analysis.The journal of headache and pain · 2025Pooled it
- Microbial composition of gastric lesions: differences based on Helicobacter pylori virulence profile.Scientific reports · 2024Article
- Electrolyzed-Reduced Water: Review II: Safety Concerns and Effectiveness as a Source of Hydrogen Water.International journal of molecular sciences · 2022Review
- Overgrowth ofWorld journal of gastrointestinal oncology · 2021Review
- The protective effect ofGut microbes · 2020Article
- Gut microbiota and butyrate level changes associated with the long-term administration of proton pump inhibitors to old rats.Scientific reports · 2019Article
- Repertoire of the gut microbiota from stomach to colon using culturomics and next-generation sequencing.BMC microbiology · 2018Article
- Using glycolysis enzyme sequences to inform Lactobacillus phylogeny.Microbial genomics · 2018Article
- Commentary: The Influence of Proton Pump Inhibitors on the Fecal Microbiome of Infants with Gastroesophageal Reflux-A Prospective Longitudinal Interventional Study.Frontiers in cellular and infection microbiology · 2018Article
- The Gastric and Intestinal Microbiome: Role of Proton Pump Inhibitors.Current gastroenterology reports · 2017Review
- Does Long-Term Proton Pump Inhibitor Therapy Affect the Health of Gut Microbiota?Gut and liver · 2016Article
- Proton Pump Inhibitors, HThe journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAGArticle
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
aimsTo evaluate changes in gut microbiota composition following long-term proton pump inhibitor (PPI) treatment.
methodsTwenty-four-week-old F344 rats were fed diets with (n=6) or without (n=5) lansoprazole for 50 weeks. Profiles of luminal microbiota in the terminal ileum were then analyzed. Pyrosequencing of the 16S rRNA gene was performed using an FLX genome sequencer (454 Life Sciences/Roche).
resultsRats treated with lansoprazole showed significantly reduced body weights compared to controls (lansoprazole-treated rats and controls, 322.3±15.3 g vs 403.2±5.2 g, respectively, p<0.001). However, stool frequencies and consistencies did not differ between the two groups. The composition of the gut microbiota in lansoprazole-treated rats was quite different from that of the controls. In the controls, the microbiota profiles obtained from the terminal ileum showed a predominance of
conclusionsThis preliminary study suggests that long-term administration of PPI may cause weight loss and changes to the microbiota in the terminal ileum.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.