Evidence map›Paper›PMID 27458158›Full record

ArticleOncotarget2016

Association between single nucleotide polymorphisms in the TSPYL6 gene and breast cancer susceptibility in the Han Chinese population.

Ming Liu, Bin Li, Wen Guo, Xiyang Zhang, Zhengshuai Chen, Jingjie Li, Mengdan Yan, Chao Chen, Tianbo Jin

Open access · diamondAbstract read
In one paragraph

Article in Oncotarget, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.8field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Genetic variations inOncotarget · 2017
    Article
  5. Oncotarget · 2017
    Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Ming LiuSchool of Life Sciences, Northwest University, Xi'an 710069, China.
Bin LiSchool of Life Sciences, Northwest University, Xi'an 710069, China.
Wen GuoInner Mongolia Medical University, Inner Mongolia, Hohhot 010050, China.
Xiyang ZhangSchool of Life Sciences, Northwest University, Xi'an 710069, China.
Zhengshuai ChenSchool of Life Sciences, Northwest University, Xi'an 710069, China.
Jingjie LiSchool of Life Sciences, Northwest University, Xi'an 710069, China.
Mengdan YanSchool of Life Sciences, Northwest University, Xi'an 710069, China.
Chao ChenSchool of Life Sciences, Northwest University, Xi'an 710069, China.
Tianbo JinSchool of Life Sciences, Northwest University, Xi'an 710069, China.
Northwest University · CNInner Mongolia Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We investigated the associations between single nucleotide polymorphisms (SNPs) in the testis-specific Y-encoded-like protein 6 (TSPYL6) gene and breast cancer (BC) susceptibility in the Han Chinese population. A total of 183 BC patients and 195 healthy women were included in the study. Six SNPs in TSPYL6 were genotyped and the association with BC risk analyzed. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated using unconditional logistic regression analysis. Multivariate logistic regression analysis was used to identify SNPs that correlated with BC susceptibility. Rs11896604 was associated with a decreased risk of BC based on dominant and genotype models. Rs843706 was associated with an increased risk of BC based on a recessive model. Rs11125529 was associated with decreased BC susceptibility based on a genotype model. Finally, rs843711 inversely correlated with clinical stage III/IV BC. Our findings reveal a significant association between SNPs in the TSPYL6 gene and BC risk in a Han Chinese population.

Indexed as

Polymorphism, Single NucleotideAdultAsian PeopleBreast NeoplasmsChinaFemaleGene FrequencyGenetic Predisposition to DiseaseGenotypeHumansLogistic ModelsMiddle AgedMultivariate AnalysisNeoplasm Stagingassociation studybreast cancersingle nucleotide polymorphismTSPYL6

Identifiers

PMID27458158
PMCPMC5342380
OpenAlexW2486213210

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.