ArticleThe Journal of biological chemistry2016
Structural Basis of Host Autophagy-related Protein 8 (ATG8) Binding by the Irish Potato Famine Pathogen Effector Protein PexRD54.
Article in The Journal of biological chemistry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 86 citations in OpenAlex.
- Selective degradation processes in plants are not limited to autophagy.Plant cell reports · 2026Review
- Pathogenicity and virulence ofVirulence · 2025Review
- Structural Insights Into the Role of RxLR Effectors in the Arms Race Between Oomycetes and Plants.Molecular plant pathology · 2025Review
- Deciphering the Molecular Interplay Between RXLR-EncodedInternational journal of molecular sciences · 2025Review
- Dynamics in theBiochemistry · 2025Article
- Atg8 family proteins, LIR/AIM motifs and other interaction modes.Autophagy reports · 2023Article
- Article
- Autophagy and its mediated mitochondrial quality control maintain pollen tube growth and male fertility in Arabidopsis.Autophagy · 2023Article
- AlphaFold2-multimer guided high-accuracy prediction of typical and atypical ATG8-binding motifs.PLoS biology · 2023Article
- Regressive evolution of an effector following a host jump in the Irish potato famine pathogen lineage.PLoS pathogens · 2022Article
- Article
- Short Linear Motifs (SLiMs) in "Core" RxLR Effectors ofMicrobiology spectrum · 2022Article
- An Overview of the Molecular Mechanisms and Functions of Autophagic Pathways in Plants.Plant signaling & behavior · 2021Article
- "Core" RxLR effectors in phytopathogenic oomycetes: A promising way to breeding for durable resistance in plants?Virulence · 2021Article
- Conserved and Diversified Mechanism of Autophagy between Plants and Animals upon Various Stresses.Antioxidants (Basel, Switzerland) · 2021Review
- Article
- Host-interactor screens of Phytophthora infestans RXLR proteins reveal vesicle trafficking as a major effector-targeted process.The Plant cell · 2021Article
- Structure, Dynamics and Function of the 26S Proteasome.Sub-cellular biochemistry · 2021Review
- Effector prediction and characterization in the oomycete pathogen Bremia lactucae reveal host-recognized WY domain proteins that lack the canonical RXLR motif.PLoS pathogens · 2020Article
- Review on Structures of Pesticide Targets.International journal of molecular sciences · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
Abstract
Filamentous plant pathogens deliver effector proteins to host cells to promote infection. The Phytophthora infestans RXLR-type effector PexRD54 binds potato ATG8 via its ATG8 family-interacting motif (AIM) and perturbs host-selective autophagy. However, the structural basis of this interaction remains unknown. Here, we define the crystal structure of PexRD54, which includes a modular architecture, including five tandem repeat domains, with the AIM sequence presented at the disordered C terminus. To determine the interface between PexRD54 and ATG8, we solved the crystal structure of potato ATG8CL in complex with a peptide comprising the effector's AIM sequence, and we established a model of the full-length PexRD54-ATG8CL complex using small angle x-ray scattering. Structure-informed deletion of the PexRD54 tandem domains reveals retention of ATG8CL binding in vitro and in planta This study offers new insights into structure/function relationships of oomycete RXLR effectors and how these proteins engage with host cell targets to promote disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.