ArticleProceedings of the National Academy of Sciences of the United States of America2016
Highly sensitive detection of influenza virus by boron-doped diamond electrode terminated with sialic acid-mimic peptide.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Recent advances in airborne pathogen detection using optical and electrochemical biosensors.Analytica chimica acta · 2022Review
- Advancements in electrochemical biosensing for respiratory virus detection: A review.Trends in analytical chemistry : TRAC · 2021Review
- Containerless Bioorganic Reactions in a Floating Droplet by Levitation Technique Using an Ultrasonic Wave.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Article
- Ultrananocrystalline Diamond Nanowires: Fabrication, Characterization, and Sensor Applications.Materials (Basel, Switzerland) · 2021Review
- Biomimetic Nanopillar-Based Biosensor for Label-Free Detection of Influenza A Virus.Biochip journal · 2021Article
- Peptides to combat viral infectious diseases.Peptides · 2020Review
- Application of spike sorting algorithm to neuronal signals originated from boron doped diamond micro-electrode arrays.Physiological research · 2020Article
- Copper(I)-Catalyzed Click Chemistry as a Tool for the Functionalization of Nanomaterials and the Preparation of Electrochemical (Bio)Sensors.Sensors (Basel, Switzerland) · 2019Review
- Antibody-free digital influenza virus counting based on neuraminidase activity.Scientific reports · 2019Article
- Review
- Recent trends in click chemistry as a promising technology for virus-related research.Virus research · 2018Review
- A rapid-response ultrasensitive biosensor for influenza virus detection using antibody modified boron-doped diamond.Scientific reports · 2017Article
- Label-free Detection of Influenza Viruses using a Reduced Graphene Oxide-based Electrochemical Immunosensor Integrated with a Microfluidic Platform.Scientific reports · 2017Article
- Recent Progress in Electrochemical Biosensors for Glycoproteins.Sensors (Basel, Switzerland) · 2016Review
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6 authors.
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Abstract
The progression of influenza varies according to age and the presence of an underlying disease; appropriate treatment is therefore required to prevent severe disease. Anti-influenza therapy, such as with neuraminidase inhibitors, is effective, but diagnosis at an early phase of infection before viral propagation is critical. Here, we show that several dozen plaque-forming units (pfu) of influenza virus (IFV) can be detected using a boron-doped diamond (BDD) electrode terminated with a sialic acid-mimic peptide. The peptide was used instead of the sialyloligosaccharide receptor, which is the common receptor of influenza A and B viruses required during the early phase of infection, to capture IFV particles. The peptide, which was previously identified by phage-display technology, was immobilized by click chemistry on the BDD electrode, which has excellent electrochemical characteristics such as low background current and weak adsorption of biomolecules. Electrochemical impedance spectroscopy revealed that H1N1 and H3N2 IFVs were detectable in the range of 20-500 pfu by using the peptide-terminated BDD electrode. Our results demonstrate that the BDD device integrated with the receptor-mimic peptide has high sensitivity for detection of a low number of virus particles in the early phase of infection.
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