Evidence map›Paper›PMID 27457487›Full record

ArticleBMC gastroenterology2016

Genetic variations of DICKKOPF family genes might not be associated with gastric cancer susceptibility.

Juan Wu, Junfeng Zhang, Zhen Zhan, Qinhong Cao, Zhong Li

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC gastroenterology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. A literature review on function and regulation mechanism of DKK4.Journal of cellular and molecular medicine · 2021
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Juan WuDepartment of Nutrition and Food Hygiene, Key Laboratory of Modern Toxicology, Ministry of Education, School of Public Health, Nanjing Medical University, 818 East Tianyuan Rd, Nanjing, China.
Junfeng ZhangDiscipline of Chinese and Western Integrative Medicine, Nanjing University of Chinese Medicine, Nanjing, China.
Zhen ZhanDiscipline of Chinese and Western Integrative Medicine, Nanjing University of Chinese Medicine, Nanjing, China.
Qinhong CaoDepartment of Digestive Tumor Surgery, Jiangsu Province Hospital of Traditional Chinese Medicine, Affiliated Hospital of Nanjing University of Traditional Chinese Medicine, Nanjing, China.
Zhong LiDepartment of Nutrition and Food Hygiene, Key Laboratory of Modern Toxicology, Ministry of Education, School of Public Health, Nanjing Medical University, 818 East Tianyuan Rd, Nanjing, China. lz-ny@njmu.edu.cn.
Nanjing University of Chinese Medicine · CNMinistry of Education · KRNanjing Traditional Chinese Medicine Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRecent studies have implicated that members of the DICKKOPF (DKK) were causally involved in large number of human cancers. This study was designed to investigate the relationship between the genetic variations of DKK family genes and the risk of gastric cancer (GC).

methodsSix SNPs (single nucleotide polymorphisms) of DKK family genes, including rs2241529 in DKK1, rs3733635, rs17037102 and rs419764 in DKK2, rs3206824 in DKK3 and rs2073664 in DKK4, were selected and genotyped by restriction fragment length polymorphism (RFLP) and TaqMan SNP genotyping methods in 409 GC cases and 554 cancer-free controls in the Han population in eastern China.

resultsNone of the six SNPs achieved significant association with the overall GC risk and stratified analysis by age, gender, smoking status, drinking status, tumor location and pathological classification confirmed these non-significant associations.

conclusionsOur study indicated that the studied six SNPs of DKKs would not be the risk factors for GC in this Han Chinese population. Studies of larger population for different ethnicities will be needed to warrant our findings.

Indexed as

Genetic VariationAdaptor Proteins, Signal TransducingAsian PeopleChemokinesFemaleGenetic Predisposition to DiseaseGenotyping TechniquesHumansIntercellular Signaling Peptides and ProteinsMaleMiddle AgedPolymorphism, Restriction Fragment LengthPolymorphism, Single NucleotideRisk FactorsStomach NeoplasmsAdaptor Proteins, Signal TransducingChemokinesDKK1 protein, humanDKK2 protein, humanDKK3 protein, humanDKK4 protein, humanIntercellular Signaling Peptides and ProteinsEpidemiologySingle nucleotide polymorphismStomach neoplasmsWnt signaling pathway

Identifiers

PMID27457487
PMCPMC4960719
OpenAlexW2499630426

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.