SynthesisScientific reports2016
Environment-Wide Association Study of Blood Pressure in the National Health and Nutrition Examination Survey (1999-2012).
Synthesis in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Design and methodology challenges of environment-wide association studies: A systematic review.Environmental research · 2020Pooled it
- Uncovering Exposure Patterns of Metals, PFAS, Phthalates, and PAHs and Their Combined Effect on Liver Injury Markers.Journal of xenobiotics · 2025Article
- Pregnancy Metal Mixtures and Blood Pressure and Hypertension in Mid-Life: A Prospective U.S. Cohort Study.Hypertension (Dallas, Tex. : 1979) · 2025Article
- The developmental trajectories and modifiable factors of adolescents' subjective well-being from late adolescence to early adulthood.Child and adolescent psychiatry and mental health · 2025Article
- Exposome-wide association study of cognition among older adults in the National Health and Nutrition Examination Survey.Exposome · 2025Article
- Differential effects of environmental exposures on clinically relevant endophenotypes between sexes.Scientific reports · 2024Article
- A spatial and contextual exposome-wide association study and polyexposomic score of COVID-19 hospitalization.Exposome · 2023Article
- Prioritization of COVID-19 risk factors in July 2020 and February 2021 in the UK.Communications medicine · 2023Article
- An exposome-wide association study on body mass index in adolescents using the National Health and Nutrition Examination Survey (NHANES) 2003-2004 and 2013-2014 data.Scientific reports · 2022Article
- Exposome-wide ranking of modifiable risk factors for cardiometabolic disease traits.Scientific reports · 2022Article
- Drug prescriptions and dementia incidence: a medication-wide association study of 17000 dementia cases among half a million participants.Journal of epidemiology and community health · 2022Article
- Identification of Novel Phenotypes Correlated with CKD: A Phenotype-Wide Association Study.International journal of medical sciences · 2022Article
- Environmental exposure to metals and the risk of high blood pressure: a cross-sectional study from NHANES 2015-2016.Environmental science and pollution research international · 2022Article
- Exposure to heavy metals and trace minerals in first trimester and maternal blood pressure change over gestation.Environment international · 2021Article
- Article
- Association of 152 Biomarker Reference Intervals with All-Cause Mortality in Participants of a General United States Survey from 1999 to 2010.Clinical chemistry · 2021Article
- What about the environment? Leveraging multi-omic datasets to characterize the environment's role in human health.Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing · 2021Article
- Genetic Epidemiology of Complex Phenotypes.Methods in molecular biology (Clifton, N.J.) · 2021Review
- A systematic comprehensive longitudinal evaluation of dietary factors associated with acute myocardial infarction and fatal coronary heart disease.Nature communications · 2020Article
- Diabetic Retinopathy Environment-Wide Association Study (EWAS) in NHANES 2005-2008.Journal of clinical medicine · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Identifying environmental exposures associated with blood pressure is a priority. Recently, we proposed the environment-wide association study to search for and replicate environmental factors associated with phenotypes. We conducted the environment-wide association study (EWAS) using the National Health and Nutrition Examination Surveys (1999-2012) which evaluated a total of 71,916 participants to prioritize environmental factors associated with systolic and diastolic blood pressure. We searched for factors on participants from survey years 1999-2006 and tentatively replicated findings in participants from years 2007-2012. Finally, we estimated the overall association and performed a second meta-analysis using all survey years (1999-2012). For systolic blood pressure, self-reported alcohol consumption emerged as our top finding (a 0.04 increase in mmHg of systolic blood pressure for 1 standard deviation increase in self-reported alcohol), though the effect size is small. For diastolic blood pressure, urinary cesium was tentatively replicated; however, this factor demonstrated high heterogeneity between populations (I(2) = 51%). The lack of associations across this wide of an analysis raises the call for a broader search for environmental factors in blood pressure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.