ArticleEpidemiology and psychiatric sciences2017
Schizophrenia among patients with systemic lupus erythematosus: population-based cross-sectional study.
Article in Epidemiology and psychiatric sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 3 syntheses or guidelines pooled it, 59 citations in OpenAlex.
- Genome-wide meta-analysis with 1,590,596 individuals identifies 12 novel risk loci for systemic lupus erythematosus.Mammalian genome : official journal of the International Mammalian Genome Society · 2026Pooled it
- Integrative analysis of genome-wide association studies identifies novel loci associated with neuropsychiatric disorders.Translational psychiatry · 2021Pooled it
- Associations Between Non-neurological Autoimmune Disorders and Psychosis: A Meta-analysis.Biological psychiatry · 2019Pooled it
- Shared genetic architecture of schizophrenia and lupus identifies pleiotropic loci with distinct downstream mechanisms.Human molecular genetics · 2026Article
- A Zebra in Horse's Clothing: Rethinking the Diagnosis of Rare Diseases.Molecular genetics & genomic medicine · 2025Review
- The relationship between schizophrenia or schizoaffective disorder and type 1 diabetes mellitus: a scoping review of observational studies.Neuropsychiatrie : Klinik, Diagnostik, Therapie und Rehabilitation : Organ der Gesellschaft Osterreichischer Nervenarzte und Psychiater · 2024Article
- Causality between autoimmune diseases and schizophrenia: a bidirectional Mendelian randomization study.BMC psychiatry · 2024Article
- An exploratory study of the damage markers NfL, GFAP, and t-Tau, in cerebrospinal fluid and other findings from a patient cohort enriched for suspected autoimmune psychiatric disease.Translational psychiatry · 2024Article
- Diagnostic progression to schizophrenia in 35,255 patients with obsessive-compulsive disorder: a longitudinal follow-up study.European archives of psychiatry and clinical neuroscience · 2023Article
- High risk of depression, anxiety, and an unfavorable complex comorbidity profile is associated with SLE: a nationwide patient-level study.Arthritis research & therapy · 2022Article
- Plasma Levels of the Cytokines B Cell-Activating Factor (BAFF) and A Proliferation-Inducing Ligand (APRIL) in Schizophrenia, Bipolar, and Major Depressive Disorder: A Cross Sectional, Multisite Study.Schizophrenia bulletin · 2022Article
- Consensus on potential biomarkers developed for use in clinical tests for schizophrenia.General psychiatry · 2022Article
- High Comorbidity Burden in Patients with SLE: Data from the Community-Based Lupus Registry of Crete.Journal of clinical medicine · 2021Article
- Immunoceptive inference: why are psychiatric disorders and immune responses intertwined?Biology & philosophy · 2021Article
- Inflammation in Mental Disorders: Is the Microbiota the Missing Link?Neuroscience bulletin · 2020Review
- Igg-Dependent Hydrolysis of Myelin Basic Protein of Patients with Different Courses of Schizophrenia.Journal of immunology research · 2020Article
- Association between Takayasu arteritis and ischemic heart disease: a cohort study.Mediterranean journal of rheumatology · 2019Article
- The link between schizophrenia and hypothyroidism: a population-based study.Immunologic research · 2018Article
- Genetic correlations among psychiatric and immune-related phenotypes based on genome-wide association data.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2018Article
- Characterization of adherence and persistence profile in a real-life population of patients treated with adalimumab.British journal of clinical pharmacology · 2018Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsSystemic lupus erythematosus (SLE) is a prototypic autoimmune disease involving multiple organs, including the central nervous system. Evidence of immune dysfunction exists also in schizophrenia, a psychiatric illness involving chronic or recurrent psychosis. The aim of our study was to investigate if there is an epidemiological association between SLE and schizophrenia.
methodA cross-sectional study was conducted comparing patients with SLE with age and gender-matched controls regarding the proportion of patients with comorbid schizophrenia. χ 2- and t-tests were used for univariate analysis, and interaction of schizophrenia with SLE across strata of covariates was checked. A logistic regression model was used for multivariate analysis. The study was performed utilising the medical database of Clalit Health Services in Israel.
resultsThe study included 5018 patients with SLE and 25 090 controls. SLE patients had a female predominance, and a higher proportion of smoking compared with age and sex-matched controls. In multivariate analysis, SLE was found to be independently associated with schizophrenia while controlling for age, gender, socioeconomic status (SES) and smoking (OR 1.33, p = 0.042).
conclusionsWe found a positive association between SLE and schizophrenia across patients of different age, gender and SES. This association can contribute to understanding the pathophysiology of the two disorders and may also have clinical implications for earlier as well as better diagnosis and treatment.
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