ArticleBMC gastroenterology2016
Type 1 and type 2 diabetes in celiac disease: prevalence and effect on clinical and histological presentation.
Article in BMC gastroenterology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Prevalence of celiac disease in Iranian patients with type 1 diabetes: A systematic review and meta-analysis.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2020Pooled it
- Article
- Celiac disease and metabolic syndrome: from risk to a preventive opportunity, in the perspective of children's health.Frontiers in nutrition · 2026Review
- The Implications of Type 1 Diabetes Mellitus Associated with Coeliac Disease.Journal of clinical medicine · 2025Review
- Pseudoascites Due to Celiac Disease in a Patient with Type 1 Diabetes.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2025Article
- European Consensus on Malabsorption-UEG & SIGE, LGA, SPG, SRGH, CGS, ESPCG, EAGEN, ESPEN, and ESPGHAN: Part 2: Screening, Special Populations, Nutritional Goals, Supportive Care, Primary Care Perspective.United European gastroenterology journal · 2025Article
- Use of Horse Chestnut (Aesculus hippocastanum L.) Starch in Gluten-Free Cakes: Physicochemical, Nutritional, Textural Properties, and Determination of Pore Structure Using Conventional Thresholding Algorithms.Journal of food science · 2025Article
- Coeliac disease: complications and comorbidities.Nature reviews. Gastroenterology & hepatology · 2025Review
- Autoimmune polyglandular syndrome among Chinese celiac disease patients: a survey of 243 individuals in China.Frontiers in immunology · 2025Article
- Coeliac disease and type 2 diabetes risk: a nationwide matched cohort and Mendelian randomisation study.Diabetologia · 2024Article
- Prevalence of markers of beta cell autoimmunity and thyroid disease in children with coeliac disease.BMC pediatrics · 2023Article
- A Clinical and Pathophysiological Overview of Intestinal and Systemic Diseases Associated with Pancreatic Disorders: Causality or Casualty?Biomedicines · 2023Review
- Celiac Disease and Cardiovascular Risk: A Retrospective Case-Control Study.Journal of clinical medicine · 2023Article
- Review
- Glycaemic Index of Gluten-Free Biscuits with Resistant Starch and Sucrose Replacers: An In Vivo and In Vitro Comparative Study.Foods (Basel, Switzerland) · 2022Article
- Gastrointestinal and Liver Complications in Patients with Diabetes Mellitus-A Review of the Literature.Journal of clinical medicine · 2022Review
- Predictors of associated and multiple autoimmunity in children and adolescents with type 1 diabetes mellitus.Annals of pediatric endocrinology & metabolism · 2022Article
- Celiac Disease Patients With Coronary Artery Disease: A Nationwide Population-Based Study.Cureus · 2022Article
- Biomarkers to Monitor Adherence to Gluten-Free Diet by Celiac Disease Patients: Gluten Immunogenic Peptides and Urinary miRNAs.Foods (Basel, Switzerland) · 2022Review
- Association of concomitant autoimmunity with the disease features and long-term treatment and health outcomes in Celiac disease.Frontiers in medicine · 2022Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAssociation between celiac disease and type 1 diabetes in adults is still somewhat unclear, and that between celiac disease and type 2 diabetes even less known. We studied these issues in a large cohort of adult celiac disease patients.
methodsThe prevalence of type 1 and type 2 diabetes in 1358 celiac patients was compared with the population-based values. Furthermore, patients with celiac disease and concomitant type 1 or type 2 diabetes and those with celiac disease only underwent comparisons of clinical and histological features and adherence to gluten-free diet.
resultsThe prevalence of type 1 diabetes (men/women) was 8.0 % /1.8 % in celiac patients and 0.7 % /0.3 % in the population, and that of type 2 diabetes 4.3 % /2.5 % and 4.4 % /3.0 %, respectively. Celiac patients with concomitant type 1 diabetes were younger (45 years vs 65 years and 52 years, P < 0.001) and more often screen-detected (43 % vs 13 % and 14 %, P < 0.001), had less other gastrointestinal diseases (8 % vs 40 % and 25 %, P = 0.028), more thyroidal diseases (18 % vs 16 % and 13 %, P = 0.043) and lower dietary adherence (71 % vs 95 % and 96 %, P < 0.001) compared with celiac patients with concomitant type 2 diabetes and patients with celiac disease only. Patients with concomitant type 2 diabetes had more hypercholesterolemia than the other groups (8 % vs 6 % and 4 %, P = 0.024), and both diabetes groups more hypertension (47 % and 31 % vs 15 %, P < 0.001) and coronary artery disease (29 % and 18 % vs 3 %, P < 0.001) than the patients with celiac disease only.
conclusionsType 1 diabetes was markedly overrepresented in celiac disease, especially in men, whereas the prevalence of type 2 diabetes was comparable with the population. Concomitant type 1 or type 2 diabetes predisposes celiac patients to severe co-morbidities and type 1 diabetes also to poor dietary adherence.
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