Evidence map›Paper›PMID 27457272›Full record

ArticleMolecular and biochemical parasitology

Distinct genomic architecture of Plasmodium falciparum populations from South Asia.

Shiva Kumar, Devaraja G Mudeppa, Ambika Sharma, Anjali Mascarenhas, Rashmi Dash, Ligia Pereira, Riaz Basha Shaik, Jennifer N Maki, John White, Wenyun Zuo and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular and biochemical parasitology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Towards an evolutionary baseline model ofbioRxiv : the preprint server for biology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Shiva KumarDepartment of Chemistry, University of Washington, Seattle, WA 98195, USA.
Devaraja G MudeppaDepartment of Chemistry, University of Washington, Seattle, WA 98195, USA.
Ambika SharmaDepartment of Chemistry, University of Washington, Seattle, WA 98195, USA; Department of Medicine, Goa Medical College and Hospital, Bambolim, Goa 403202, India.
Anjali MascarenhasDepartment of Chemistry, University of Washington, Seattle, WA 98195, USA; Department of Medicine, Goa Medical College and Hospital, Bambolim, Goa 403202, India.
Rashmi DashDepartment of Chemistry, University of Washington, Seattle, WA 98195, USA; Department of Medicine, Goa Medical College and Hospital, Bambolim, Goa 403202, India.
Ligia PereiraDepartment of Chemistry, University of Washington, Seattle, WA 98195, USA; Department of Medicine, Goa Medical College and Hospital, Bambolim, Goa 403202, India.
Riaz Basha ShaikDepartment of Chemistry, University of Washington, Seattle, WA 98195, USA; Department of Medicine, Goa Medical College and Hospital, Bambolim, Goa 403202, India.
Jennifer N MakiDepartment of Chemistry, University of Washington, Seattle, WA 98195, USA.
John WhiteDepartment of Chemistry, University of Washington, Seattle, WA 98195, USA.
Wenyun ZuoDepartment of Biology, Stanford University, Stanford, CA 94305, USA.
Shripad TuljapurkarDepartment of Biology, Stanford University, Stanford, CA 94305, USA.
Manoj T DuraisinghDepartment of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, MA 02115 USA.
Edwin GomesDepartment of Medicine, Goa Medical College and Hospital, Bambolim, Goa 403202, India.
Laura CheryDepartment of Chemistry, University of Washington, Seattle, WA 98195, USA.
Pradipsinh K RathodDepartment of Chemistry, University of Washington, Seattle, WA 98195, USA. Electronic address: rathod@chem.washington.edu.

Funding

Shared TechnologyU19AI089688 · NIAID · UNIVERSITY OF WASHINGTON · PI TULJAPURKAR, SHRIPAD D. · 2010 to 2023
$22.4M
Chemical Genomics for Antimalarial TargetsR01AI099280 · NIAID · UNIVERSITY OF WASHINGTON · PI RATHOD, PRADIPSINH K. · 2012 to 2016
$2.5M
NIAID NIH HHS R01 AI099280NIAID NIH HHS U19 AI089688
6 · The paper itself

Abstract

Previous whole genome comparisons of Plasmodium falciparum populations have not included collections from the Indian subcontinent, even though two million Indians contract malaria and about 50,000 die from the disease every year. Stratification of global parasites has revealed spatial relatedness of parasite genotypes on different continents. Here, genomic analysis was further improved to obtain country-level resolution by removing var genes and intergenic regions from distance calculations. P. falciparum genomes from India were found to be most closely related to each other. Their nearest neighbors were from Bangladesh and Myanmar, followed by Thailand. Samples from the rest of Southeast Asia, Africa and South America were increasingly more distant, demonstrating a high-resolution genomic-geographic continuum. Such genome stratification approaches will help monitor variations of malaria parasites within South Asia and future changes in parasite populations that may arise from in-country and cross-border migrations.

Indexed as

Genome, ProtozoanGenomicsAsiaGenetics, PopulationGenetic VariationGenotypeHumansIndiaMalaria, FalciparumPhylogenyPlasmodium falciparumEpidemiologyMalariaMolecularNeighborsPopulations

Identifiers

PMID27457272
PMCPMC5249597

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.