Evidence map›Paper›PMID 27457271›Full record

Trial reportTwin research and human genetics : the official journal of the International Society for Twin Studies2016

The Twin Study of Negative Valence Emotional Constructs.

Dever M Carney, Elizabeth Moroney, Laura Machlin, Shannon Hahn, Jeanne E Savage, Minyoung Lee, Kenneth A Towbin, Melissa A Brotman, Daniel S Pine, Ellen Leibenluft and 2 more

Abstract readClinical TrialMulticenter StudyTwin Study
In one paragraph

Trial report in Twin research and human genetics : the official journal of the International Society for Twin Studies, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Structural Brain Correlates of Childhood Inhibited Temperament: An ENIGMA-Anxiety Mega-Analysis.Journal of the American Academy of Child and Adolescent Psychiatry · 2026
    Article
  2. Article
  3. Article
  4. Children's Mental Health in Southwestern Ontario during Summer 2020 of the COVID-19 Pandemic.Journal of the Canadian Academy of Child and Adolescent Psychiatry = Journal de l'Academie canadienne de psychiatrie de l'enfant et de l'adolescent · 2021
    Article
  5. Article
  6. Article
  7. Article
  8. The genetic and environmental structure of fear and anxiety in juvenile twins.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2019
    Article
  9. The Genetic and Environmental Relationship Between Childhood Behavioral Inhibition and Preadolescent Anxiety.Twin research and human genetics : the official journal of the International Society for Twin Studies · 2019
    Article
  10. A Developmental Twin Study of Emotion Recognition and Its Negative Affective Clinical Correlates.Journal of the American Academy of Child and Adolescent Psychiatry · 2018
    Article
  11. Article
  12. Article
  13. Genetic and Environmental Contributions of Negative Valence Systems to Internalizing Pathways.Twin research and human genetics : the official journal of the International Society for Twin Studies · 2018
    Article
  14. Article
  15. Clinical Correlates of Carbon Dioxide Hypersensitivity in Children.Journal of the American Academy of Child and Adolescent Psychiatry · 2017
    Article
  16. Article
  17. Article
  18. Article
  19. A Population-Based Twin Study of Childhood Irritability and Internalizing Syndromes.Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Dever M CarneyVirginia Institute for Psychiatric and Behavioral Genetics and Department of Psychiatry,Virginia Commonwealth University,Richmond,Virginia,USA.
Elizabeth MoroneyEmotion and Development Branch,National Institute of Mental Health,National Institutes of Health,Department of Health and Human Services,Bethesda,Maryland,USA.
Laura MachlinEmotion and Development Branch,National Institute of Mental Health,National Institutes of Health,Department of Health and Human Services,Bethesda,Maryland,USA.
Shannon HahnVirginia Institute for Psychiatric and Behavioral Genetics and Department of Psychiatry,Virginia Commonwealth University,Richmond,Virginia,USA.
Jeanne E SavageVirginia Institute for Psychiatric and Behavioral Genetics and Department of Psychiatry,Virginia Commonwealth University,Richmond,Virginia,USA.
Minyoung LeeVirginia Institute for Psychiatric and Behavioral Genetics and Department of Psychiatry,Virginia Commonwealth University,Richmond,Virginia,USA.
Kenneth A TowbinEmotion and Development Branch,National Institute of Mental Health,National Institutes of Health,Department of Health and Human Services,Bethesda,Maryland,USA.
Melissa A BrotmanEmotion and Development Branch,National Institute of Mental Health,National Institutes of Health,Department of Health and Human Services,Bethesda,Maryland,USA.
Daniel S PineEmotion and Development Branch,National Institute of Mental Health,National Institutes of Health,Department of Health and Human Services,Bethesda,Maryland,USA.
Ellen LeibenluftEmotion and Development Branch,National Institute of Mental Health,National Institutes of Health,Department of Health and Human Services,Bethesda,Maryland,USA.
Roxann Roberson-NayVirginia Institute for Psychiatric and Behavioral Genetics and Department of Psychiatry,Virginia Commonwealth University,Richmond,Virginia,USA.
John M HettemaVirginia Institute for Psychiatric and Behavioral Genetics and Department of Psychiatry,Virginia Commonwealth University,Richmond,Virginia,USA.

Funding

fMRI Studies Of Pediatric Mood And Anxiety DisordersZIAMH002781 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI PINE, DANIEL · 2009 to 2025
$41.5M
The Pathophysiology and Treatment Of Children With Severe Mood DysregulationZIAMH002786 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI LEIBENLUFT, ELLEN · 2009 to 2023
$34.0M
Center for Clinical and Translational ResearchUL1TR000058 · NCATS · VIRGINIA COMMONWEALTH UNIVERSITY · PI MOELLER, FREDERICK GERARD · 2012 to 2015
$12.5M
The Phenomenology And Neurophysiology Of Juvenile Bipolar DisorderZIAMH002778 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI LEIBENLUFT, ELLEN · 2009 to 2017
$10.8M
Research Training: Psychiatric &Statistical GeneticsT32MH020030 · NIMH · VIRGINIA COMMONWEALTH UNIVERSITY · PI HERMINE H MAES, MICHAEL CHURTON NEALE · 1999 to 2026
$6.7M
A Twin Study of Negative Valence Emotional ConstructsR01MH098055 · NIMH · VIRGINIA COMMONWEALTH UNIVERSITY · PI HETTEMA, JOHN M · 2012 to 2014
$1.6M
Fmri Studies Of Pediatric Mood And Anxiety DisordersZ01MH002781 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI PINE, DANIEL · 2002 to 2008
$1.5M
Intramural NIH HHS Z01 MH002781NCATS NIH HHS UL1 TR000058NIMH NIH HHS R01 MH098055NIMH NIH HHS T32 MH020030
6 · The paper itself

Abstract

The Twin Study of Negative Valence Emotional Constructs is a multi-site study designed to examine the relationship between a broad selection of potential measures designed to assess putative endophenotypes for negative valence systems (NVS) and early symptoms of internalizing disorders (IDs). In this article, we describe the sample characteristics, data collection protocols, and measures used. Pre-adolescent Caucasian twin pairs were recruited through the Mid-Atlantic Twin Registry; data collection began in February of 2013. Enrolled twins completed various dimensional self-report measures along with cognitive, emotional, and psychophysiological tasks designed to assess NVS function. Parents also completed surveys about their twins and themselves. In addition, a subset of the twins also participated in a neuroimaging protocols. Data collection is in the final stages, and preliminary analyses are underway. The findings will potentially expand our understanding of the mechanisms by which genetic and environmental factors contribute to individual differences in NVS phenotypes and provide new insights into underlying risk factors for IDs.

Indexed as

Anxiety DisordersEmotionsRegistriesAdolescentChildFemaleHumansMaleTwinsanxietyinternalizingnegative valencetwin study

Identifiers

PMID27457271
PMCPMC5371400

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.