ArticleDiagnostic pathology2016
Multiple lesions of gastrointestinal tract invasion by monomorphic epitheliotropic intestinal T-cell lymphoma, accompanied by duodenal and intestinal enteropathy-like lesions and microscopic lymphocytic proctocolitis: a case series.
Article in Diagnostic pathology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Colonic neoplasia and celiac disease: A systematic review.World journal of gastroenterology · 2025Pooled it
- Multiple Elective Surgeries and Cord Blood Transplantation for Multi-refractory Monomorphic Epitheliotropic Intestinal T-cell Lymphoma.Internal medicine (Tokyo, Japan) · 2026Article
- Abdominal pain and jaundice secondary to duodenal monomorphic epitheliotropic intestinal T-cell lymphoma.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2026Article
- Long-term disease control of monomorphic epitheliotrophic intestinal T-cell lymphoma (MEITL) with CNS involvement in a caucasian patient by allogeneic hematopoietic cell transplantation.Bone marrow transplantation · 2026Article
- Monomorphic Epitheliotropic Intestinal T-Cell Lymphoma: A Case of Extranodal Non-Hodgkin Lymphoma in the Jejunum with Invasion of the Abdominal Wall and Transverse Colon.Surgical case reports · 2026Article
- Monomorphic epitheliotropic intestinal T-cell lymphoma with gallbladder involvement: A case report.Molecular and clinical oncology · 2025Article
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- Characterization of primary small intestinal lymphoma: a retrospective study based on double balloon endoscopy.BMC gastroenterology · 2024Article
- Surgical management of monomorphic epitheliotropic intestinal T-cell lymphoma followed by chemotherapy and stem-cell transplant: A case report and review of the literature.World journal of gastrointestinal oncology · 2022Article
- Cellular Origins and Pathogenesis of Gastrointestinal NK- and T-Cell Lymphoproliferative Disorders.Cancers · 2022Review
- Initial and advanced endoscopic findings of monomorphic epitheliotropic intestinal T-cell lymphoma in the duodenum: A case report.DEN open · 2022Article
- Pancreatoduodenectomy for monomorphic epitheliotropic intestinal T-cell lymphoma with duodenal obstruction.BMJ case reports · 2022Article
- Monomorphic epitheliotropic intestinal T-cell lymphoma presenting as melena with long-term survival: A case report and review of literature.World journal of gastroenterology · 2021Review
- Small bowel T-cell lymphoma: a MEITL-ing diagnosis.Clinical journal of gastroenterology · 2021Article
- Endoscopic and clinicopathological characteristics of colorectal T/NK cell lymphoma.Diagnostic pathology · 2020Article
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- Monomorphic Epitheliotropic Intestinal T Cell Lymphoma of the Appendix: a Case Report and Review of Literature.Journal of gastrointestinal cancer · 2020Review
- Monomorphic Epitheliotropic Intestinal T cell Lymphoma: a Rare Cause of Chronic Diarrhea.Journal of gastrointestinal cancer · 2019Article
- Endoscopic and clinicopathological characteristics of gastrointestinal adult T-cell leukemia/lymphoma.Journal of gastrointestinal oncology · 2019Article
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn East Asia, monomorphic epitheliotropic intestinal T-cell lymphoma (MEITL), previously known as type II enteropathy-associated T-cell lymphoma (EATL), occurs more frequently than type I EATL, and coeliac disease is rare. CASE PRESENTATION: Here we present four cases of MEITL in Japanese patients, including the endoscopic and pathological findings of their duodenal and colorectal lesions. Tumor specimens obtained from duodenal, intestinal, and colorectal biopsies in all four patients showed a diffuse intramucosal infiltration of small to/or medium-sized lymphoma cells and numerous atypical intraepithelial lymphocytes (IELs). These cells were immunohistologically positive for CD103, CD3, CD7, CD8, CD56, and T-cell intracellular antigen-1. Upper and lower gastrointestinal and antegrade double-balloon endoscopy revealed foci of edematous mucosa, with or without villous atrophy, in the non-neoplastic mucosa. Histological studies demonstrated duodenal and intestinal enteropathy-like lesions as well as microscopic (lymphocytic) proctocolitis with increased CD3- and CD8-positive and CD56-negative T-IELs in all four patients. The clinicopathological findings of the non-neoplastic lesions were similar to those characteristic of coeliac disease, suggesting that variants of coeliac disease may be present in the prodromal lesions of MEITL.
conclusionsOur study supports the need for random gastrointestinal biopsies to determine tumor spread, the features of MEITL in the particular patients, and the presence of prodromal non-neoplastic lesions.
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