Evidence map›Paper›PMID 27457183›Full record

ArticleEuropean journal of immunology2016

Escherichia coli Nissle 1917 protects gnotobiotic pigs against human rotavirus by modulating pDC and NK-cell responses.

Anastasia N Vlasova, Lulu Shao, Sukumar Kandasamy, David D Fischer, Abdul Rauf, Stephanie N Langel, Kuldeep S Chattha, Anand Kumar, Huang-Chi Huang, Gireesh Rajashekara and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of immunology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 43 citations in OpenAlex.

  1. Current and emerging approaches to manage chronic inflammatory gut disorders.Frontiers in cellular and infection microbiology · 2026
    Review
  2. Review
  3. Article
  4. Article
  5. Oral Immunization withBiomolecules · 2023
    Article
  6. Effects ofIranian journal of veterinary research · 2023
    Article
  7. Article
  8. Review
  9. Next-Generation Probiotics for Inflammatory Bowel Disease.International journal of molecular sciences · 2022
    Review
  10. Vaccines · 2022
    Article
  11. Review
  12. Article
  13. Effects ofFrontiers in microbiology · 2022
    Article
  14. Review
  15. Review
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Anastasia N VlasovaVeterinary Preventive Medicine Department, Food Animal Health Research Program (FAHRP), The Ohio Agricultural Research and Development Center, The Ohio State University, Wooster, OH, USA. vlasova.1@osu.edu.
Lulu ShaoVeterinary Preventive Medicine Department, Food Animal Health Research Program (FAHRP), The Ohio Agricultural Research and Development Center, The Ohio State University, Wooster, OH, USA.
Sukumar KandasamyVeterinary Preventive Medicine Department, Food Animal Health Research Program (FAHRP), The Ohio Agricultural Research and Development Center, The Ohio State University, Wooster, OH, USA.
David D FischerVeterinary Preventive Medicine Department, Food Animal Health Research Program (FAHRP), The Ohio Agricultural Research and Development Center, The Ohio State University, Wooster, OH, USA.
Abdul RaufVeterinary Preventive Medicine Department, Food Animal Health Research Program (FAHRP), The Ohio Agricultural Research and Development Center, The Ohio State University, Wooster, OH, USA.
Stephanie N LangelVeterinary Preventive Medicine Department, Food Animal Health Research Program (FAHRP), The Ohio Agricultural Research and Development Center, The Ohio State University, Wooster, OH, USA.
Kuldeep S ChatthaVeterinary Preventive Medicine Department, Food Animal Health Research Program (FAHRP), The Ohio Agricultural Research and Development Center, The Ohio State University, Wooster, OH, USA.
Anand KumarVeterinary Preventive Medicine Department, Food Animal Health Research Program (FAHRP), The Ohio Agricultural Research and Development Center, The Ohio State University, Wooster, OH, USA.
Huang-Chi HuangVeterinary Preventive Medicine Department, Food Animal Health Research Program (FAHRP), The Ohio Agricultural Research and Development Center, The Ohio State University, Wooster, OH, USA.
Gireesh RajashekaraVeterinary Preventive Medicine Department, Food Animal Health Research Program (FAHRP), The Ohio Agricultural Research and Development Center, The Ohio State University, Wooster, OH, USA.
Linda J SaifVeterinary Preventive Medicine Department, Food Animal Health Research Program (FAHRP), The Ohio Agricultural Research and Development Center, The Ohio State University, Wooster, OH, USA.
The Ohio State University · US

Funding

Gut microflora: Impact on neonatal immunity, viral gastroenteritis and vaccinesR01AI099451 · NIAID · OHIO STATE UNIVERSITY · PI RAJASHEKARA, GIREESH, SAIF, LINDA J. · 2012 to 2016
$2.2M
NIAID NIH HHS R01 AI099451
6 · The paper itself

Abstract

Lactobacillus rhamnosus GG (LGG), a gram-positive lactic acid bacterium, is one of the most widely used probiotics; while fewer gram-negative probiotics including Escherichia coli Nissle 1917 (EcN) are characterized. A mechanistic understanding of their individual and interactive effects on human rotavirus (HRV) and immunity is lacking. In this study, noncolonized, EcN-, LGG-, and EcN + LGG-colonized neonatal gnotobiotic (Gn) pigs were challenged with HRV. EcN colonization is associated with a greater protection against HRV, and induces the highest frequencies of plasmacytoid dendritic cells (pDCs), significantly increased NK-cell function and decreased frequencies of apoptotic and TLR4

Indexed as

AnimalsCell DifferentiationCells, CulturedCytokinesCytotoxicity, ImmunologicDendritic CellsEscherichia coliEscherichia coli InfectionsGerm-Free LifeHumansImmunity, InnateInflammation MediatorsIntestinal MucosaKiller Cells, NaturalLacticaseibacillus rhamnosusLymphocyte ActivationCytokinesInflammation MediatorsChildhood diarrheaDendritic cellsE. coli Nissle 1917Human rotavirusL. rhamnosus GGNatural killer cellsProbiotics

Identifiers

PMID27457183
PMCPMC5201163
OpenAlexW2484348635

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.