Evidence map›Paper›PMID 27457100›Full record

ArticleOsteoarthritis and cartilage2016

Role of thigh muscle cross-sectional area and strength in progression of knee cartilage degeneration over 48 months - data from the Osteoarthritis Initiative.

L H Goldman, K Tang, L Facchetti, U Heilmeier, G B Joseph, M C Nevitt, C E McCulloch, R B Souza, T M Link

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Osteoarthritis and cartilage, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 2 pooled it
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 29 citations in OpenAlex.

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  12. Epidemiology of osteoarthritis: literature update.Current opinion in rheumatology · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 4 countries.

L H GoldmanDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, USA; Department of Radiology, Montefiore Medical Center, USA. Electronic address: lhackney@montefiore.org.
K TangDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, USA. Electronic address: kennethtangd1@yahoo.com.
L FacchettiDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, USA; Department of Radiology, University of Brescia, Brescia, Italy. Electronic address: fachettil@gmail.com.
U HeilmeierDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, USA. Electronic address: ursula.heilmeier@ucsf.edu.
G B JosephDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, USA. Electronic address: gabby.joseph@ucsf.edu.
M C NevittDepartment of Epidemiology and Biostatistics, University of California, San Francisco, USA. Electronic address: mnevitt@psg.ucsf.edu.
C E McCullochDepartment of Epidemiology and Biostatistics, University of California, San Francisco, USA. Electronic address: charles.mcculloch@ucsf.edu.
R B SouzaDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, USA; Department of Physical Therapy and Rehabilitation Science, University of California, San Francisco, USA. Electronic address: richard.souza@ucsf.edu.
T M LinkDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, USA. Electronic address: thomas.link@ucsf.edu.
University of California, San Francisco · USMontefiore Medical Center · US

Funding

Translation of Quantitative Imaging in OsteoarthritisP50AR060752 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SOUZA, RICHARD BRIAN · 2011 to 2015
$6.2M
UCSF Core Center for Musculoskeletal Biology and MedicineP30AR066262 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LOTZ, JEFFREY C. · 2014 to 2018
$3.0M
NIAMS NIH HHS P30 AR066262NIAMS NIH HHS P50 AR060752
6 · The paper itself

Abstract

objectiveTo determine in a 48-month longitudinal study the association of thigh muscle cross-sectional area (CSA) and strength on progression of morphologic knee cartilage degeneration using 3T magnetic resonance imaging (MRI).

designSeventy Osteoarthritis Initiative (OAI) subjects aged 50-60 years, with no radiographic evidence of osteoarthritis (OA) and constant muscle strength over 48 months as measured by isometric knee extension testing were included. Baseline right thigh muscle CSAs were assessed on axial T1-weighted magnetic resonance (MR) images, and extensor to flexor CSA ratios were calculated. Degenerative knee abnormalities at baseline and 48-months were graded on right knee 3T MRIs using a modified whole organ MRI score (WORMS). Statistical analysis employed Student's t-tests and multivariable regression models adjusted for age, body mass index and gender.

resultsExtension strength was significantly and positively correlated with baseline thigh muscle CSA (r = 0.65, P < 0.001). Greater baseline total thigh muscle CSA was significantly associated with increase of cartilage WORMS scores over 48 months in patellar (P = 0.027) and trochlear (P = 0.038) compartments, but not in other knee compartments. Among specific muscle groups, CSA of extensors (P = 0.021) and vastus medialis (VM) (P = 0.047) were associated with patellar cartilage increase in WORMS. Baseline E/F ratio had a significant positive association with patellar WORMS cartilage score increase over 48 months, P = 0.0015. There were no other significant associations between muscle CSA/ratios and increase in WORMS scores.

conclusionMaintenance of proper extensor to flexor muscle balance about the knee through decreased E/F ratios may slow patellofemoral cartilage deterioration, while higher extensor and VM CSA may increase patellofemoral cartilage loss.

Indexed as

ThighCartilage, ArticularHumansKneeKnee JointLongitudinal StudiesMagnetic Resonance ImagingMuscle StrengthOsteoarthritis, KneeCartilageExtension strengthKneeMR imagingMuscle cross-sectional areaOsteoarthritis

Identifiers

PMID27457100
PMCPMC5614519
OpenAlexW2488505835

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.