Evidence map›Paper›PMID 27456966›Full record

ArticleEuropean radiology2017

Hepatic stiffness measurement by using MR elastography: prognostic values after hepatic resection for hepatocellular carcinoma.

Dong Ho Lee, Jeong Min Lee, Nam-Joon Yi, Kwang-Woong Lee, Kyung-Suk Suh, Jeong-Hoon Lee, Kyung Bun Lee, Joon Koo Han

Abstract readEvaluation Study
PubMed Publisher
In one paragraph

Article in European radiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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  18. New frontiers in liver resection for hepatocellular carcinoma.JHEP reports : innovation in hepatology · 2020
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  19. Article
  20. Updates on Imaging of Liver Tumors.Current oncology reports · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Dong Ho LeeDepartment of Radiology, Seoul National University Hospital, 101 Daehangno, Jongno-gu, Seoul, 110-744, Korea.
Jeong Min LeeDepartment of Radiology, Seoul National University Hospital, 101 Daehangno, Jongno-gu, Seoul, 110-744, Korea. jmsh@snu.ac.kr.
Nam-Joon YiDepartment of Surgery, Seoul National University Hospital, Seoul, Korea.
Kwang-Woong LeeDepartment of Surgery, Seoul National University Hospital, Seoul, Korea.
Kyung-Suk SuhDepartment of Surgery, Seoul National University Hospital, Seoul, Korea.
Jeong-Hoon LeeDepartment of Internal Medicine, Seoul National University Hospital, Seoul, Korea.
Kyung Bun LeeDepartment of Pathology, Seoul National University Hospital, Seoul, Korea.
Joon Koo HanDepartment of Radiology, Seoul National University Hospital, 101 Daehangno, Jongno-gu, Seoul, 110-744, Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo evaluate prognostic value of hepatic stiffness (HS) measurement using MR elastography (MRE) in patients with hepatocellular carcinoma (HCC) treated by hepatic resection (HR).

methodsWe enrolled 144 patients with Barcelona Clinic Liver Cancer stage A HCCs initially treated by HR who underwent preoperative liver MRE between January 2010 and June 2013. HS values were measured using MRE. Receiver operating characteristics (ROC) and multivariate logistic regression analyses were used to determine significant predictive factors for posthepatecomy liver failure (PHLF). Overall survival (OS) was analyzed by evaluating prognostic factors using the Kaplan-Meier method and Cox proportional hazard regression model.

resultsAfter HR, 43 patients (29.9 %) experienced PHLF. HS values were significant predictive factors for PHLF. In ROC analysis, the area under the curve of HS was 0.740 (P = 0.001) for PHLF. Thirty-one patients had HS values ≥ 4.02 kPa; the estimated 1, 3, 5-year survival were 90.0 %, 74.7 % and 65.4 %, respectively, versus 98.1 %, 96.5 % and 96.5 % in 113 patients with HS values < 4.02 kPa (P = 0.015). An HS value ≥ 4.02 kPa was the only significant affecting factor for OS.

conclusionHS values measured by MRE could predict PHLF development post-HR. Furthermore, an HS value ≥4.02 kPa was a significant predicting factor for poor OS post-HR. KEY POINTS: • Hepatic stiffness value was a predictive factor for developing posthepatectomy liver failure • Hepatic stiffness value was a significant affecting factor for OS • Hepatic stiffness value ≥ 4.02 kPa was a predictive factor for poor OS.

Indexed as

AdultAgedCarcinoma, HepatocellularElasticity Imaging TechniquesFemaleHepatectomyHumansKaplan-Meier EstimateLiver FailureLiver NeoplasmsMaleMiddle AgedPrognosisRetrospective StudiesROC CurveHepatic stiffness valueHepatocellular carcinomaMagnetic resonance elastographyOverall survivalPosthepatectomy liver failure

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.