ReviewJournal of molecular biology2016
Avoidance and Subversion of Eukaryotic Homeostatic Autophagy Mechanisms by Bacterial Pathogens.
Review in Journal of molecular biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed.
- Avian pathogenic Escherichia coli virulence protein Hcp2a induces incomplete autophagy in chicken HD11 cells.Poultry science · 2026Article
- Article
- Progress in brucellosis immune regulation inflammatory mechanisms and diagnostic advances.European journal of medical research · 2025Review
- Targeting BamA, the essential component of theHeliyon · 2024Article
- Article
- Identification ofFrontiers in cellular and infection microbiology · 2022Article
- Article
- The host mTOR pathway and parasitic diseases pathogenesis.Parasitology research · 2021Review
- Cryptosporidium parvum infection induces autophagy in intestinal epithelial cells.Cellular microbiology · 2021Article
- The first case of microsporidiosis inParasitology · 2020Article
- Do cells use passwords in cell-state transitions? Is cell signaling sometimes encrypted?Theory in biosciences = Theorie in den Biowissenschaften · 2020Article
- Hostile Takeover: Hijacking of Endoplasmic Reticulum Function by T4SS and T3SS Effectors Creates a Niche for Intracellular Pathogens.Microbiology spectrum · 2019Article
- Diverse Facets of Sphingolipid Involvement in Bacterial Infections.Frontiers in cell and developmental biology · 2019Review
- Natural variation in the roles of C. elegans autophagy components during microsporidia infection.PloS one · 2019Article
- [Role of p38MAPK signaling pathway in autophagy of Henle-407 cells induced by spvB of Salmonella typhimurium].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2018Article
- Review
- Listeria monocytogenes switches from dissemination to persistence by adopting a vacuolar lifestyle in epithelial cells.PLoS pathogens · 2017Article
- Methods to Monitor and Quantify Autophagy in the Social Amoeba Dictyostelium discoideum.Cells · 2017Review
- Absence of Specific Chlamydia trachomatis Inclusion Membrane Proteins Triggers Premature Inclusion Membrane Lysis and Host Cell Death.Cell reports · 2017Article
- Importance of Metabolic Adaptations inFrontiers in cellular and infection microbiology · 2017Review
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Autophagy is a conserved lysosomal recycling process, which maintains cellular homeostasis during stress and starvation conditions by degrading and recycling proteins, lipids, and carbohydrates, ultimately increasing nutrient availability in eukaryotes. An additional function of autophagy, termed xenophagy, is to detect, capture, and destroy invading microorganisms, such as viruses, bacteria, and protozoa, providing autophagy with a role in innate immunity. Many intracellular pathogens have, however, developed mechanisms to avoid xenophagy and have evolved strategies to take advantage of select autophagic processes to undergo their intracellular life cycle. This review article will discuss the molecular mechanisms used by the intracellular bacterial pathogens Francisella spp. and Brucella spp. to manipulate components of the autophagic pathway, promoting cytosolic growth in the case of Francisella spp. and facilitating cellular egress and cell-to-cell spread in the case of Brucella spp. These examples highlight how successful, highly infectious bacterial pathogens avoid or subvert host autophagy mechanisms normally employed to maintain eukaryotic homeostasis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.