Evidence map›Paper›PMID 27456849›Full record

ReviewSeminars in immunopathology2017

Dendritic cells as gatekeepers of tolerance.

Ari Waisman, Dominika Lukas, Björn E Clausen, Nir Yogev

Abstract readReview
PubMed Publisher
In one paragraph

Review in Seminars in immunopathology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 150 papers.

0numbers the graph read from it
0cells of the map it votes in
150citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

150 citing papers in PubMed, 235 citations in OpenAlex.

  1. Trial
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  6. Article
  7. Article
  8. Regulation of mCell biology and toxicology · 2026
    Review
  9. Review
  10. Eutopic Endometrium Immune Changes Involved in Development and Progression of Endometriosis: A Review.Medical science monitor : international medical journal of experimental and clinical research · 2026
    Review
  11. Review
  12. Review
  13. Review
  14. Targeting Talin1 to reprogram dendritic cell activation landscapes: A mechanistically grounded cell therapy for multiple sclerosis model.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025
    Article
  15. Review
  16. Article
  17. Review
  18. Review
  19. The multifaceted role of SMAD4 in immune cell function.Biochemistry and biophysics reports · 2025
    Review
  20. Review

90 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Ari WaismanInstitute for Molecular Medicine, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany. waisman@uni-mainz.de.ORCID 0000-0003-4304-8234
Dominika LukasInstitute for Molecular Medicine, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.
Björn E ClausenInstitute for Molecular Medicine, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.
Nir YogevInstitute for Molecular Medicine, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.
Johannes Gutenberg University Mainz · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dendritic cells (DC) are unique hematopoietic cells, linking innate and adaptive immune responses. In particular, they are considered as the most potent antigen presenting cells, governing both T cell immunity and tolerance. In view of their exceptional ability to present antigen and to interact with T cells, DC play distinct roles in shaping T cell development, differentiation and function. The outcome of the DC-T cell interaction is determined by the state of DC maturation, the type of DC subset, the cytokine microenvironment and the tissue location. Both regulatory T cells (Tregs) and DC are indispensable for maintaining central and peripheral tolerance. Over the past decade, accumulating data indicate that DC critically contribute to Treg differentiation and homeostasis.

Indexed as

Immune ToleranceAnimalsAntigen PresentationAutoimmune DiseasesBiomarkersCell CommunicationCell DifferentiationDendritic CellsHomeostasisHumansImmunotherapyOrgan SpecificityPhenotypeSignal TransductionT-Lymphocyte SubsetsBiomarkersDendritic cellsRegulatory T cellsTolerance induction

Identifiers

PMID27456849
OpenAlexW2504484095

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.