Evidence map›Paper›PMID 27456841›Full record

ArticleNutrition journal2016

Association of the tumor necrosis factor-alpha promoter polymorphism with change in triacylglycerol response to sequential meals.

Kim G Jackson, Yue Li, Miriam F Ryan, Eileen R Gibney, Lorraine Brennan, Helen M Roche, Christine M Williams, Julie A Lovegrove, Karani S Vimaleswaran

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrition journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01172951 (A Nutrigenomics Study of Post-prandial Metabolic Responses in Individuals of Varying Body Weight), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01172951 nacompletednot on this map

A Nutrigenomics Study of Post-prandial Metabolic Responses in Individuals of Varying Body Weight: An Assessment of the Body's Response to Meals Containing Different Levels of Fat and Carbohydrate

TypeinterventionalSponsorUniversity College DublinRan2008 to 2010Enrolled200ConditionsHealthy SubjectsArmsOral glucose tolerance test, Oral lipid tolerance test
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Kim G JacksonHugh Sinclair Unit of Human Nutrition, Department of Food and Nutritional Sciences, University of Reading, Reading, UK.
Yue LiHugh Sinclair Unit of Human Nutrition, Department of Food and Nutritional Sciences, University of Reading, Reading, UK.
Miriam F RyanUCD Institute of Food & Health, University College Dublin, Dublin, Ireland.
Eileen R GibneyUCD Institute of Food & Health, University College Dublin, Dublin, Ireland.
Lorraine BrennanUCD Institute of Food & Health, University College Dublin, Dublin, Ireland.
Helen M RocheUCD Institute of Food & Health, University College Dublin, Dublin, Ireland.
Christine M WilliamsInstitute for Cardiovascular and Metabolic Research (ICMR), University of Reading, Reading, UK.
Julie A LovegroveHugh Sinclair Unit of Human Nutrition, Department of Food and Nutritional Sciences, University of Reading, Reading, UK.
Karani S VimaleswaranHugh Sinclair Unit of Human Nutrition, Department of Food and Nutritional Sciences, University of Reading, Reading, UK. v.karani@reading.ac.uk.
University of Reading · GBUniversity College Dublin · IE

Funding

Biotechnology and Biological Sciences Research Council D18350
6 · The paper itself

Abstract

backgroundReported associations between Tumor Necrosis Factor-alpha (TNFA) and the postprandial triacylglycerol (TAG) response have been inconsistent, which could be due to variations in the TNFA gene, meal fat composition or participant's body weight. Hence, we investigated the association of TNFA polymorphism (-308G → A) with body mass index (BMI) and postprandial lipaemia and also determined the impact of BMI on the association of the polymorphism with postprandial lipaemia.

methodsThe study participants (n = 230) underwent a sequential meal postprandial study. Blood samples were taken at regular intervals after a test breakfast (t = 0, 49 g fat) and lunch (t =330 min, 29 g fat) to measure fasting and postprandial lipids, glucose and insulin. The Metabolic Challenge Study (MECHE) comprising 67 Irish participants who underwent a 54 g fat oral lipid tolerance test was used as a replication cohort. The impact of genotype on postprandial responses was determined using general linear model with adjustment for potential confounders.

resultsThe -308G → A polymorphism showed a significant association with BMI (P = 0.03) and fasting glucose (P = 0.006), where the polymorphism explained 13 % of the variation in the fasting glucose. A 30 % higher incremental area under the curve (IAUC) was observed for the postprandial TAG response in the GG homozygotes than A-allele carriers (P = 0.004) and the genotype explained 19 % of the variation in the IAUC. There was a non-significant trend in the impact of BMI on the association of the genotype with TAG IAUC (P = 0.09). These results were not statistically significant in the MECHE cohort, which could be due to the differences in the sample size, meal composition, baseline lipid profile, allelic diversity and postprandial characterisation of participants across the two cohorts.

conclusionsOur findings suggest that TNFA -308G → A polymorphism may be an important candidate for BMI, fasting glucose and postprandial TAG response. Further studies are required to investigate the mechanistic effects of the polymorphism on glucose and TAG metabolism, and determine whether BMI is an important variable which should be considered in the design of future studies.

trial registrationNCT01172951 .

Indexed as

Polymorphism, GeneticPromoter Regions, GeneticAdolescentAdultAgedBlood GlucoseBody Mass IndexCholesterolCohort StudiesFastingFatty Acids, NonesterifiedFemaleGenotyping TechniquesHumansHyperlipidemiasInsulinBlood GlucoseCholesterolFatty Acids, NonesterifiedInsulinTriglyceridesTumor Necrosis Factor-alphaBMIMECHEPostprandial lipaemiaTNFA promoter polymorphismTriacylglycerol

Identifiers

PMID27456841
PMCPMC4960705
OpenAlexW2499990744

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.