Evidence map›Paper›PMID 27456839›Full record

GuidelineJournal of nephrology2016

Metabolic diagnosis and medical prevention of calcium nephrolithiasis and its systemic manifestations: a consensus statement.

Giovanni Gambaro, Emanuele Croppi, Fredric Coe, James Lingeman, Orson Moe, Elen Worcester, Noor Buchholz, David Bushinsky, Gary C Curhan, Pietro Manuel Ferraro and 15 more

Open access · hybridAbstract readConsensus StatementPractice GuidelineSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Guideline in Journal of nephrology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 105 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
105citing papers in PubMed, 6 pooled it
17.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

105 citing papers in PubMed, 6 syntheses or guidelines pooled it, 166 citations in OpenAlex.

  1. Pooled it
  2. Dent disease: clinical practice recommendations.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2025
    Guideline
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45 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors at 12 institutions in 7 countries.

Giovanni GambaroDepartment of Nephrology and Dialysis, A. Gemelli University Hospital, Catholic University of the Sacred Heart, Rome, Italy.
Emanuele Croppi, A.S.L. 10, Florence, Italy. emcroppi@mark.it.
Fredric CoeDepartment of Nephrology, University of Chicago Medicine, Chicago, USA.
James LingemanDepartment of Urology, Indiana University School of Medicine, Indianapolis, USA.
Orson MoeDepartment of Internal Medicine, Southwestern Medical Center, University of Texas, Dallas, USA.
Elen WorcesterDepartment of Nephrology, University of Chicago Medicine, Chicago, USA.
Noor BuchholzDepartment of Urological Surgery, Sobeh's Vascular and Medical Center, Dubai, UAE.
David BushinskyDepartment of Nephrology, Medical Center, University of Rochester, Rochester, USA.
Gary C CurhanRenal Division, Brigham and Women's Hospital, Boston, USA.
Pietro Manuel FerraroDepartment of Nephrology and Dialysis, A. Gemelli University Hospital, Catholic University of the Sacred Heart, Rome, Italy.
Daniel FusterDepartment of Nephrology, University of Bern, Bern, Switzerland.
David S GoldfarbDepartment of Nephrology, New York Harbor VA Health Care System, New York, USA.
Ita Pfeferman HeilbergDepartment of Nephrology, Sao Paulo University, Sao Paulo, Brazil.
Bernard HessDepartment of Internal Medicine and Nephrology, Klinik Im Park Hospital, Zurich, Switzerland.
John LieskeDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, USA.
Martino MarangellaDepartment of Nephrology, A.S.O Ordine Mauriziano Hospital, Turin, Italy.
Dawn MillinerDepartment of Nephrology, Mayo Clinic, Rochester, USA.
Glen M PremingerDepartment of Urology, Duke University Medical Center, Durham, USA.
Jose' Manuel Reis SantosDepartment of Urology, Catholic University of Portugal, Lisbon, Portugal.
Khashayar SakhaeeSouthwestern Medical Center, Mineral Metabolism Research, University of Texas, Dallas, USA.
Kemal SaricaDepartment of Urology, Dr. Lutfi KIRDAR Kartal Research and Training Hospital, Istanbul, Turkey.
Roswitha SienerDepartment of Urology, University of Bonn, Bonn, Germany.
Pasquale StrazzulloDepartment of Internal Medicine, University of Naples, Naples, Italy.
James C WilliamsDepartment of Anatomy and Cell Biology, Indiana University School of Medicine, Indiana, USA.
Consensus Conference Group
Mayo Clinic · USUniversità Cattolica del Sacro Cuore · ITUniversity of Chicago · USIndiana University School of MedicineUniversidade Católica Portuguesa · PTUniversidade de São Paulo · BRUniversity of Bonn · DEBrigham and Women's Hospital · USDr Lütfi Kırdar Kartal Eğitim ve Araştırma Hastanesi · TRSouthwestern Medical CenterUniversity of Bern · CHUniversity of Rochester Medical Center · US

Funding

SWL AND RENAL INJURY AND STONE COMMINUTIONP01DK043881 · NIDDK · UNIVERSITY OF WASHINGTON · PI LIU, ZIYUE · 1994 to 2023
$33.5M
NIDDK NIH HHS P01 DK043881
6 · The paper itself

Abstract

backgroundRecently published guidelines on the medical management of renal stone disease did not address relevant topics in the field of idiopathic calcium nephrolithiasis, which are important also for clinical research.

designA steering committee identified 27 questions, which were proposed to a faculty of 44 experts in nephrolithiasis and allied fields. A systematic review of the literature was conducted and 5216 potentially relevant articles were selected; from these, 407 articles were deemed to provide useful scientific information. The Faculty, divided into working groups, analysed the relevant literature. Preliminary statements developed by each group were exhaustively discussed in plenary sessions and approved.

resultsStatements were developed to inform clinicians on the identification of secondary forms of calcium nephrolithiasis and systemic complications; on the definition of idiopathic calcium nephrolithiasis; on the use of urinary tests of crystallization and of surgical observations during stone treatment in the management of these patients; on the identification of patients warranting preventive measures; on the role of fluid and nutritional measures and of drugs to prevent recurrent episodes of stones; and finally, on the cooperation between the urologist and nephrologist in the renal stone patients.

conclusionsThis document has addressed idiopathic calcium nephrolithiasis from the perspective of a disease that can associate with systemic disorders, emphasizing the interplay needed between urologists and nephrologists. It is complementary to the American Urological Association and European Association of Urology guidelines. Future areas for research are identified.

Indexed as

UrinalysisBiomarkersCalciumConsensusCrystallizationHumansInterdisciplinary CommunicationNephrolithiasisNephrologistsPatient Care TeamPredictive Value of TestsRecurrenceRisk FactorsSecondary PreventionTreatment OutcomeUrologistsBiomarkersCalciumBeveragesBone diseaseCKDDietNephrolithiasisRenal tubular acidosis

Identifiers

PMID27456839
PMCPMC5080344
OpenAlexW2481567338

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.