ArticleScientific reports2016
New cosurface capacitive stimulators for the development of active osseointegrative implantable devices.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 35 citations in OpenAlex.
- Bioelectronic osteosynthesis plate to monitor the fracture bone healing using electric capacitive variations.Journal of orthopaedic surgery and research · 2025Article
- A millimetre-scale capacitive biosensing and biophysical stimulation system for emerging bioelectronic bone implants.Journal of the Royal Society, Interface · 2024Article
- Gathering Evidence to Leverage Musculoskeletal Magnetic Stimulation Towards Clinical Applicability.Small science · 2024Article
- The application of impantable sensors in the musculoskeletal system: a review.Frontiers in bioengineering and biotechnology · 2024Review
- Sensor Technology in Fracture Healing.Indian journal of orthopaedics · 2023Review
- Bioreactor analyses of tissue ingrowth, ongrowth and remodelling around implants: An alternative to live animal testing.Frontiers in bioengineering and biotechnology · 2023Article
- Bioelectronic multifunctional bone implants: recent trends.Bioelectronic medicine · 2022Review
- Multiscale Sensing of Bone-Implant Loosening for Multifunctional Smart Bone Implants: Using Capacitive Technologies for Precision Controllability.Sensors (Basel, Switzerland) · 2022Article
- Multifunctional Smart Bone Implants: Fiction or Future?-A New Perspective.Frontiers in bioengineering and biotechnology · 2022Article
- Long-term stimulation with alternating electric fields modulates the differentiation and mineralization of human pre-osteoblasts.Frontiers in physiology · 2022Article
- Capacitive interdigitated system of high osteoinductive/conductive performance for personalized acting-sensing implants.NPJ Regenerative medicine · 2021Article
- Performance of a Piezoelectric Energy Harvesting System for an Energy-Autonomous Instrumented Total Hip Replacement: Experimental and Numerical Evaluation.Materials (Basel, Switzerland) · 2021Article
- Endurance testing and finite element simulation of a modified hip stem for integration of an energy harvesting system.Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine · 2021Article
- Towards an effective sensing technology to monitor micro-scale interface loosening of bioelectronic implants.Scientific reports · 2021Article
- Natural and Eco-Friendly Materials for Triboelectric Energy Harvesting.Nano-micro letters · 2020Review
- Altering the Course of Technologies to Monitor Loosening States of Endoprosthetic Implants.Sensors (Basel, Switzerland) · 2019Review
- Capacitive technologies for highly controlled and personalized electrical stimulation by implantable biomedical systems.Scientific reports · 2019Article
- Implanted Battery-Free Direct-Current Micro-Power Supply from in Vivo Breath Energy Harvesting.ACS applied materials & interfaces · 2018Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Non-drug strategies based on biophysical stimulation have been emphasized for the treatment and prevention of musculoskeletal conditions. However, to date, an effective stimulation system for intracorporeal therapies has not been proposed. This is particularly true for active intramedullary implants that aim to optimize osseointegration. The increasing demand for these implants, particularly for hip and knee replacements, has driven the design of innovative stimulation systems that are effective in bone-implant integration. In this paper, a new cosurface-based capacitive system concept is proposed for the design of implantable devices that deliver controllable and personalized electric field stimuli to target tissues. A prototype architecture of this system was constructed for in vitro tests, and its ability to deliver controllable stimuli was numerically analyzed. Successful results were obtained for osteoblastic proliferation and differentiation in the in vitro tests. This work provides, for the first time, a design of a stimulation system that can be embedded in active implantable devices for controllable bone-implant integration and regeneration. The proposed cosurface design holds potential for the implementation of novel and innovative personalized stimulatory therapies based on the delivery of electric fields to bone cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.