Evidence map›Paper›PMID 27456681›Full record

ReviewNutrition journal2016

The importance of antioxidants which play the role in cellular response against oxidative/nitrosative stress: current state.

Ergul Belge Kurutas

Open access · goldAbstract readReview
In one paragraph

Review in Nutrition journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 749 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
749citing papers in PubMed, 2 pooled it
14.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

749 citing papers in PubMed, 2 syntheses or guidelines pooled it, 2,124 citations in OpenAlex.

  1. Pooled it
  2. Antioxidant supplementation for sickle cell disease.The Cochrane database of systematic reviews · 2024
    Pooled it
  3. Trial
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  9. Function ofInsects · 2026
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  12. Review
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689 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Ergul Belge KurutasDepartment of Medical Biochemistry, Faculty of Medicine, Sutcu Imam University, Avsar Campus, Kahramanmaras, 46050, Turkey. ergulkurutas@gmail.com.
Kahramanmaraş Sütçü İmam University · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Remarkable interest has risen in the idea that oxidative/nitrosative stress is mediated in the etiology of numerous human diseases. Oxidative/Nitrosative stress is the result of an disequilibrium in oxidant/antioxidant which reveals from continuous increase of Reactive Oxygen and Reactive Nitrogen Species production. The aim of this review is to emphasize with current information the importance of antioxidants which play the role in cellular responce against oxidative/nitrosative stress, which would be helpful in enhancing the knowledge of any biochemist, pathophysiologist, or medical personnel regarding this important issue. Products of lipid peroxidation have commonly been used as biomarkers of oxidative/nitrosative stress damage. Lipid peroxidation generates a variety of relatively stable decomposition end products, mainly α, β-unsaturated reactive aldehydes, such as malondialdehyde, 4-hydroxy-2-nonenal, 2-propenal (acrolein) and isoprostanes, which can be measured in plasma and urine as an indirect index of oxidative/nitrosative stress. Antioxidants are exogenous or endogenous molecules that mitigate any form of oxidative/nitrosative stress or its consequences. They may act from directly scavenging free radicals to increasing antioxidative defences. Antioxidant deficiencies can develop as a result of decreased antioxidant intake, synthesis of endogenous enzymes or increased antioxidant utilization. Antioxidant supplementation has become an increasingly popular practice to maintain optimal body function. However, antoxidants exhibit pro-oxidant activity depending on the specific set of conditions. Of particular importance are their dosage and redox conditions in the cell.

Indexed as

Oxidative StressAntioxidantsDietary SupplementsGene Expression RegulationHumansLipid PeroxidationProtein KinasesProtein Tyrosine PhosphatasesRandomized Controlled Trials as TopicReactive Nitrogen SpeciesReactive Oxygen SpeciesTranscription FactorsAntioxidantsProtein KinasesProtein Tyrosine PhosphatasesReactive Nitrogen SpeciesReactive Oxygen SpeciesTranscription FactorsAntioxidantsOxidative/Nitrosative stressReactive oxygen and reactive nitrogen species

Identifiers

PMID27456681
PMCPMC4960740
OpenAlexW2485662396

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.