ArticleHypertension (Dallas, Tex. : 1979)2016
Association of Parental Hypertension With Arterial Stiffness in Nonhypertensive Offspring: The Framingham Heart Study.
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Article in Hypertension (Dallas, Tex. : 1979), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21citing papers in PubMed
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Who cites it
21 citing papers in PubMed, 37 citations in OpenAlex.
- Pulsatile Hemodynamics of Prehypertension and Hypertension: Associations with Pressure and Sex.Annals of biomedical engineering · 2026Article
- Higher systemic vascular resistance in individuals with a family history of hypertension.Journal of hypertension · 2025Article
- The Impact of Maternal/In Utero Exposure of Novel Tobacco Products on the Offspring Cardiovascular Health.Cardiovascular toxicology · 2025Review
- Impact of diabetes and glycemic status on ventricular-arterial coupling in the general population.Cardiovascular diabetology · 2025Article
- Modifiable risk factors and risk of myocardial infarction in offspring with parental disease.European journal of preventive cardiology · 2025Article
- Vascular dysfunction is associated with major adverse cardiovascular events in prediabetes: A cohort study.PloS one · 2025Observational
- Maternal electronic cigarette use during pregnancy affects long-term arterial function in offspring.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Article
- Improved arterial stiffness after combined aerobic and resistance training: correlation with heart rate variability change in prehypertensive offspring of hypertensive parents.Journal of exercise rehabilitation · 2022Article
- Accelerated Early Vascular Aging Among Adolescents With Obesity and/or Type 2 Diabetes Mellitus.Journal of the American Heart Association · 2020Article
- Combined effect of weight gain within normal weight range and parental hypertension on the prevalence of hypertension; from the J-MICC Study.Journal of human hypertension · 2020Article
- 70-year legacy of the Framingham Heart Study.Nature reviews. Cardiology · 2019Review
- Vascular function and stiffness: population epidemiology and concordance in Australian children aged 11-12 years and their parents.BMJ open · 2019Article
- Cardiovascular disease family history and risk of pregnancy loss.Annals of epidemiology · 2019Observational
- Incorporation of Novel Vascular Measures into Clinical Management: Recent Insights from the Framingham Heart Study.Current hypertension reports · 2019Review
- Association of Endothelial Function with Parental Hypertension in Normotensive-Obese African-American Women: A Pilot Study.Advances in preventive medicine · 2019Article
- Arterial Hemodynamics in Prehypertensives.International journal of hypertension · 2019Article
- Combined association of cardiorespiratory fitness and family history of hypertension on the incidence of hypertension: a long-term cohort study of Japanese males.Hypertension research : official journal of the Japanese Society of Hypertension · 2018Article
- Aortic stiffness, pressure and flow pulsatility, and target organ damage.Journal of applied physiology (Bethesda, Md. : 1985) · 2018Review
- Epidemiology of cardiovascular disease in young individuals.Nature reviews. Cardiology · 2018Review
- Hypertension genetic risk score is associated with burden of coronary heart disease among patients referred for coronary angiography.PloS one · 2018Observational
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Authors and funding
10 authors at 4 institutions in 2 countries.
Charlotte AnderssonFrom Boston University's and the National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, MA (C.A., M.G.L., D.L., E.J.B., R.S.V.); Section of Cardiology, Department of Internal Medicine, Glostrup Hospital, Denmark (C.A.); Cardiology Clinic of San Antonio, TX (R.Q.); Department of Epidemiology (D.E., E.J.B., R.S.V.) and Department of Biostatistics (M.G.L.), Boston University School of Public Health, MA; Department of Mathematics and Statistics, Boston University, MA (M.G.L.); Whitaker Cardiovascular Institute (N.M.H., J.A.V., E.J.B., R.S.V.) and Section of Preventive Medicine and Epidemiology (E.J.B., R.S.V.), Boston University School of Medicine, MA; National Heart, Lung and Blood Institute, Bethesda, MD (D.L.); and Cardiovascular Engineering, Inc, Norwood, MA (G.F.M.). ca@heart.dk.
Rene QuirozFrom Boston University's and the National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, MA (C.A., M.G.L., D.L., E.J.B., R.S.V.); Section of Cardiology, Department of Internal Medicine, Glostrup Hospital, Denmark (C.A.); Cardiology Clinic of San Antonio, TX (R.Q.); Department of Epidemiology (D.E., E.J.B., R.S.V.) and Department of Biostatistics (M.G.L.), Boston University School of Public Health, MA; Department of Mathematics and Statistics, Boston University, MA (M.G.L.); Whitaker Cardiovascular Institute (N.M.H., J.A.V., E.J.B., R.S.V.) and Section of Preventive Medicine and Epidemiology (E.J.B., R.S.V.), Boston University School of Medicine, MA; National Heart, Lung and Blood Institute, Bethesda, MD (D.L.); and Cardiovascular Engineering, Inc, Norwood, MA (G.F.M.).
Danielle EnserroFrom Boston University's and the National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, MA (C.A., M.G.L., D.L., E.J.B., R.S.V.); Section of Cardiology, Department of Internal Medicine, Glostrup Hospital, Denmark (C.A.); Cardiology Clinic of San Antonio, TX (R.Q.); Department of Epidemiology (D.E., E.J.B., R.S.V.) and Department of Biostatistics (M.G.L.), Boston University School of Public Health, MA; Department of Mathematics and Statistics, Boston University, MA (M.G.L.); Whitaker Cardiovascular Institute (N.M.H., J.A.V., E.J.B., R.S.V.) and Section of Preventive Medicine and Epidemiology (E.J.B., R.S.V.), Boston University School of Medicine, MA; National Heart, Lung and Blood Institute, Bethesda, MD (D.L.); and Cardiovascular Engineering, Inc, Norwood, MA (G.F.M.).
Martin G LarsonFrom Boston University's and the National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, MA (C.A., M.G.L., D.L., E.J.B., R.S.V.); Section of Cardiology, Department of Internal Medicine, Glostrup Hospital, Denmark (C.A.); Cardiology Clinic of San Antonio, TX (R.Q.); Department of Epidemiology (D.E., E.J.B., R.S.V.) and Department of Biostatistics (M.G.L.), Boston University School of Public Health, MA; Department of Mathematics and Statistics, Boston University, MA (M.G.L.); Whitaker Cardiovascular Institute (N.M.H., J.A.V., E.J.B., R.S.V.) and Section of Preventive Medicine and Epidemiology (E.J.B., R.S.V.), Boston University School of Medicine, MA; National Heart, Lung and Blood Institute, Bethesda, MD (D.L.); and Cardiovascular Engineering, Inc, Norwood, MA (G.F.M.).
Naomi M HamburgFrom Boston University's and the National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, MA (C.A., M.G.L., D.L., E.J.B., R.S.V.); Section of Cardiology, Department of Internal Medicine, Glostrup Hospital, Denmark (C.A.); Cardiology Clinic of San Antonio, TX (R.Q.); Department of Epidemiology (D.E., E.J.B., R.S.V.) and Department of Biostatistics (M.G.L.), Boston University School of Public Health, MA; Department of Mathematics and Statistics, Boston University, MA (M.G.L.); Whitaker Cardiovascular Institute (N.M.H., J.A.V., E.J.B., R.S.V.) and Section of Preventive Medicine and Epidemiology (E.J.B., R.S.V.), Boston University School of Medicine, MA; National Heart, Lung and Blood Institute, Bethesda, MD (D.L.); and Cardiovascular Engineering, Inc, Norwood, MA (G.F.M.).
Joseph A VitaFrom Boston University's and the National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, MA (C.A., M.G.L., D.L., E.J.B., R.S.V.); Section of Cardiology, Department of Internal Medicine, Glostrup Hospital, Denmark (C.A.); Cardiology Clinic of San Antonio, TX (R.Q.); Department of Epidemiology (D.E., E.J.B., R.S.V.) and Department of Biostatistics (M.G.L.), Boston University School of Public Health, MA; Department of Mathematics and Statistics, Boston University, MA (M.G.L.); Whitaker Cardiovascular Institute (N.M.H., J.A.V., E.J.B., R.S.V.) and Section of Preventive Medicine and Epidemiology (E.J.B., R.S.V.), Boston University School of Medicine, MA; National Heart, Lung and Blood Institute, Bethesda, MD (D.L.); and Cardiovascular Engineering, Inc, Norwood, MA (G.F.M.).
Daniel LevyFrom Boston University's and the National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, MA (C.A., M.G.L., D.L., E.J.B., R.S.V.); Section of Cardiology, Department of Internal Medicine, Glostrup Hospital, Denmark (C.A.); Cardiology Clinic of San Antonio, TX (R.Q.); Department of Epidemiology (D.E., E.J.B., R.S.V.) and Department of Biostatistics (M.G.L.), Boston University School of Public Health, MA; Department of Mathematics and Statistics, Boston University, MA (M.G.L.); Whitaker Cardiovascular Institute (N.M.H., J.A.V., E.J.B., R.S.V.) and Section of Preventive Medicine and Epidemiology (E.J.B., R.S.V.), Boston University School of Medicine, MA; National Heart, Lung and Blood Institute, Bethesda, MD (D.L.); and Cardiovascular Engineering, Inc, Norwood, MA (G.F.M.).
Emelia J BenjaminFrom Boston University's and the National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, MA (C.A., M.G.L., D.L., E.J.B., R.S.V.); Section of Cardiology, Department of Internal Medicine, Glostrup Hospital, Denmark (C.A.); Cardiology Clinic of San Antonio, TX (R.Q.); Department of Epidemiology (D.E., E.J.B., R.S.V.) and Department of Biostatistics (M.G.L.), Boston University School of Public Health, MA; Department of Mathematics and Statistics, Boston University, MA (M.G.L.); Whitaker Cardiovascular Institute (N.M.H., J.A.V., E.J.B., R.S.V.) and Section of Preventive Medicine and Epidemiology (E.J.B., R.S.V.), Boston University School of Medicine, MA; National Heart, Lung and Blood Institute, Bethesda, MD (D.L.); and Cardiovascular Engineering, Inc, Norwood, MA (G.F.M.).
Gary F MitchellFrom Boston University's and the National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, MA (C.A., M.G.L., D.L., E.J.B., R.S.V.); Section of Cardiology, Department of Internal Medicine, Glostrup Hospital, Denmark (C.A.); Cardiology Clinic of San Antonio, TX (R.Q.); Department of Epidemiology (D.E., E.J.B., R.S.V.) and Department of Biostatistics (M.G.L.), Boston University School of Public Health, MA; Department of Mathematics and Statistics, Boston University, MA (M.G.L.); Whitaker Cardiovascular Institute (N.M.H., J.A.V., E.J.B., R.S.V.) and Section of Preventive Medicine and Epidemiology (E.J.B., R.S.V.), Boston University School of Medicine, MA; National Heart, Lung and Blood Institute, Bethesda, MD (D.L.); and Cardiovascular Engineering, Inc, Norwood, MA (G.F.M.).
Ramachandran S VasanFrom Boston University's and the National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, MA (C.A., M.G.L., D.L., E.J.B., R.S.V.); Section of Cardiology, Department of Internal Medicine, Glostrup Hospital, Denmark (C.A.); Cardiology Clinic of San Antonio, TX (R.Q.); Department of Epidemiology (D.E., E.J.B., R.S.V.) and Department of Biostatistics (M.G.L.), Boston University School of Public Health, MA; Department of Mathematics and Statistics, Boston University, MA (M.G.L.); Whitaker Cardiovascular Institute (N.M.H., J.A.V., E.J.B., R.S.V.) and Section of Preventive Medicine and Epidemiology (E.J.B., R.S.V.), Boston University School of Medicine, MA; National Heart, Lung and Blood Institute, Bethesda, MD (D.L.); and Cardiovascular Engineering, Inc, Norwood, MA (G.F.M.).
National Heart Lung and Blood Institute · USCardiovascular Institute of the South · USGlostrup Hospital · DKNorwood Hospital · US
Funding
Framingham Project/LevyZIAHL006001 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI LEVY, DANIEL · 2009 to 2025
$51.1MVascular Stiffness as a Precursor of Hypertension in a Middle-aged CohortR01HL126136 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI MITCHELL, GARY FRANK, RAMACHANDRAN, VASAN S · 2015 to 2018
$2.6MAortic Dysfunction, Pulsatile Stress and Target Organ Damage in FraminghamR01HL107385 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI MITCHELL, GARY FRANK, RAMACHANDRAN, VASAN S · 2011 to 2014
$2.6MTHE FRAMINGHAM HEART STUDY-N01HC25195-268025195-268025195N01HC025195 · HC · TRUSTEES OF BOSTON UNIVERSITY · PI WOLF, PHILIP A · 2002 to 2006
–NHLBI NIH HHS HHSN268201500001INHLBI NIH HHS N01 HC025195NHLBI NIH HHS R01 HL107385NHLBI NIH HHS R01 HL126136
Abstract
High arterial stiffness seems to be causally involved in the pathogenesis of hypertension. We tested the hypothesis that offspring of parents with hypertension may display higher arterial stiffness before clinically manifest hypertension, given that hypertension is a heritable condition. We compared arterial tonometry measures in a sample of 1564 nonhypertensive Framingham Heart Study third-generation cohort participants (mean age: 38 years; 55% women) whose parents were enrolled in the Framingham Offspring Study. A total of 468, 715, and 381 participants had 0 (referent), 1, and 2 parents with hypertension. Parental hypertension was associated with greater offspring mean arterial pressure (multivariable-adjusted estimate=2.9 mm Hg; 95% confidence interval, 1.9-3.9, and 4.2 mm Hg; 95% confidence interval, 2.9-5.5, for 1 and 2 parents with hypertension, respectively; P<0.001 for both) and with greater forward pressure wave amplitude (1.6 mm Hg; 95% confidence interval, 0.6-2.7, and 1.9 mm Hg; 95% confidence interval, 0.6-3.2, for 1 and 2 parents with hypertension, respectively; P=0.003 for both). Carotid-femoral pulse wave velocity and augmentation index displayed similar dose-dependent relations with parental hypertension in sex-, age-, and height-adjusted models, but associations were attenuated on further adjustment. Offspring with at least 1 parent in the upper quartile of augmentation index and carotid-femoral pulse wave velocity had significantly higher values themselves (P≤0.02). In conclusion, in this community-based sample of young, nonhypertensive adults, we observed greater arterial stiffness in offspring of parents with hypertension. These observations are consistent with higher vascular stiffness at an early stage in the pathogenesis of hypertension.
Indexed as
Child of Impaired ParentsGenetic Predisposition to DiseaseAdultAge FactorsAnalysis of VarianceBlood PressureBlood Pressure DeterminationCardiovascular DiseasesCohort StudiesFemaleHumansHypertensionIncidenceMaleManometryMiddle Agedadultatherosclerosisblood pressurehypertensionphenotype
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