ReviewEuropean journal of applied physiology2016
Fatigue associated with prolonged graded running.
Review in European journal of applied physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 3 syntheses or guidelines pooled it, 103 citations in OpenAlex.
- Relationship of Carbohydrate Intake during a Single-Stage One-Day Ultra-Trail Race with Fatigue Outcomes and Gastrointestinal Problems: A Systematic Review.International journal of environmental research and public health · 2021Pooled it
- Overuse-Related Injuries of the Musculoskeletal System: Systematic Review and Quantitative Synthesis of Injuries, Locations, Risk Factors and Assessment Techniques.Sensors (Basel, Switzerland) · 2021Pooled it
- Biomechanical Response of the Lower Extremity to Running-Induced Acute Fatigue: A Systematic Review.Frontiers in physiology · 2021Pooled it
- Muscle, Neuromuscular, and Cardiac Damage in Trail Running: A Systematic Review.Muscles (Basel, Switzerland) · 2026Review
- The impact of pole use on vertical cost of transport and foot force during uphill treadmill walking before and after a simulated trail running competition.European journal of applied physiology · 2026Article
- Effects of fatigue on the activation characteristics and synergistic patterns of lower limb muscles during running.Frontiers in physiology · 2026Article
- Real-Time Performance Prediction in Long-Distance Trail Running: A Practical Model Based on Terrain Difficulty and Pacing Variability.Sports (Basel, Switzerland) · 2025Article
- The influence of prolonged aerobic exercise on cardiac, muscular, and renal biomarkers in trained individuals with obesity.European journal of applied physiology · 2025Article
- A review of uphill and downhill running: biomechanics, physiology and modulating factors.Frontiers in bioengineering and biotechnology · 2025Review
- Early marathon running metrics from inertial measurement units predict significant pace reduction.Frontiers in sports and active living · 2025Article
- Rating of Perceived Exertion: A Large Cross-Sectional Study Defining Intensity Levels for Individual Physical Activity Recommendations.Sports medicine - open · 2024Article
- Downhill running increases markers of muscle damage and impairs the maximal voluntary force production as well as the late phase of the rate of voluntary force development.European journal of applied physiology · 2024Article
- Analysis of over 1 million race records shows runners from East African countries as the fastest in 50-km ultra-marathons.Scientific reports · 2024Article
- Limits of Ultra: Towards an Interdisciplinary Understanding of Ultra-Endurance Running Performance.Sports medicine (Auckland, N.Z.) · 2024Review
- Spatiotemporal parameters and kinematics differ between race stages in trail running-a field study.Frontiers in sports and active living · 2024Article
- Running Economy in the Vertical Kilometer.Sensors (Basel, Switzerland) · 2023Article
- Relationship between biomechanics and energy cost in graded treadmill running.Scientific reports · 2023Article
- Increased oxygen uptake in well-trained runners during uphill high intensity running intervals: A randomized crossover testing.Frontiers in physiology · 2023Article
- Quantifying and correcting for speed and stride frequency effects on running mechanics in fatiguing outdoor running.Frontiers in sports and active living · 2023Article
- A Pilot Study of Plantar Mechanics Distributions and Fatigue Profiles after Running on a Treadmill: Using a Support Vector Machine Algorithm.Journal of healthcare engineering · 2023Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Scientific experiments on running mainly consider level running. However, the magnitude and etiology of fatigue depend on the exercise under consideration, particularly the predominant type of contraction, which differs between level, uphill, and downhill running. The purpose of this review is to comprehensively summarize the neurophysiological and biomechanical changes due to fatigue in graded running. When comparing prolonged hilly running (i.e., a combination of uphill and downhill running) to level running, it is found that (1) the general shape of the neuromuscular fatigue-exercise duration curve as well as the etiology of fatigue in knee extensor and plantar flexor muscles are similar and (2) the biomechanical consequences are also relatively comparable, suggesting that duration rather than elevation changes affects neuromuscular function and running patterns. However, 'pure' uphill or downhill running has several fatigue-related intrinsic features compared with the level running. Downhill running induces severe lower limb tissue damage, indirectly evidenced by massive increases in plasma creatine kinase/myoglobin concentration or inflammatory markers. In addition, low-frequency fatigue (i.e., excitation-contraction coupling failure) is systematically observed after downhill running, although it has also been found in high-intensity uphill running for different reasons. Indeed, low-frequency fatigue in downhill running is attributed to mechanical stress at the interface sarcoplasmic reticulum/T-tubule, while the inorganic phosphate accumulation probably plays a central role in intense uphill running. Other fatigue-related specificities of graded running such as strategies to minimize the deleterious effects of downhill running on muscle function, the difference of energy cost versus heat storage or muscle activity changes in downhill, level, and uphill running are also discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.