Evidence map›Paper›PMID 27456166›Full record

ArticleOrganic letters2016

Photoswitchable Spiropyran Dyads for Biological Imaging.

Yaoyao Xiong, Pablo Rivera-Fuentes, Erdinc Sezgin, Andreas Vargas Jentzsch, Christian Eggeling, Harry L Anderson

Open access · hybridAbstract read
In one paragraph

Article in Organic letters, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 60 citations in OpenAlex.

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  7. Molecular design and synthesis of methoxy-substitued spiropyrans with photomodulated NIR-fluorescence.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2023
    Article
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  15. Super-resolution optical microscopy for studying membrane structure and dynamics.Journal of physics. Condensed matter : an Institute of Physics journal · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Yaoyao XiongDepartment of Chemistry, Chemistry Research Laboratory, University of Oxford , Oxford OX1 3TA, U.K.
Pablo Rivera-FuentesDepartment of Chemistry, Chemistry Research Laboratory, University of Oxford , Oxford OX1 3TA, U.K.
Erdinc SezginMRC Human Immunology Unit and Wolfson Imaging Centre Oxford, Weatherall Institute of Molecular Medicine, University of Oxford , Oxford OX3 9DS, U.K.
Andreas Vargas JentzschDepartment of Chemistry, Chemistry Research Laboratory, University of Oxford , Oxford OX1 3TA, U.K.
Christian EggelingMRC Human Immunology Unit and Wolfson Imaging Centre Oxford, Weatherall Institute of Molecular Medicine, University of Oxford , Oxford OX3 9DS, U.K.
Harry L AndersonDepartment of Chemistry, Chemistry Research Laboratory, University of Oxford , Oxford OX1 3TA, U.K.
University of Oxford · GBMRC Weatherall Institute of Molecular Medicine · GB

Funding

Biotechnology and Biological Sciences Research CouncilMedical Research Council G0902418Medical Research Council MC_UU_12010/9Medical Research Council MR/K01577X/1Wellcome Trust
6 · The paper itself

Abstract

The synthesis of a small-molecule dyad consisting of a far-red-emitting silicon rhodamine dye that is covalently linked to a photochromic spironaphthothiopyran unit, which serves as a photoswitchable quencher, is reported. This system can be switched reversibly between the fluorescent and nonfluorescent states using visible light at wavelengths of 405 and 630 nm, respectively, and it works effectively in aqueous solution. Live-cell imaging demonstrates that this dyad has several desirable features, including excellent membrane permeability, fast and reversible modulation of fluorescence by visible light, and good contrast between the bright and dark states.

Indexed as

Cell SurvivalBenzopyransFluorescent DyesIndolesMolecular StructureNitro CompoundsOptical ImagingPhotochemical ProcessesRhodaminesBenzopyransFluorescent DyesIndolesNitro CompoundsRhodaminesspiropyran

Identifiers

PMID27456166
PMCPMC5010358
OpenAlexW2480681854

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.