Evidence map›Paper›PMID 27455842›Full record

Trial reportBMC musculoskeletal disorders2016

Peri-articular tranexamic acid injection in total knee arthroplasty: a randomized controlled trial.

P Pinsornsak, S Rojanavijitkul, S Chumchuen

2 registry-linked trialsOpen access · goldAbstract readComparative StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC musculoskeletal disorders, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 25 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 6 pooled it
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02829346 phase2completednot on this map

Peri-articular Tranexamic Acid Injection in Total Knee Arthroplasty: A Randomized Controlled Trial

TypeinterventionalSponsorThammasat UniversityRan2012 to 2013Enrolled60ConditionsOsteoarthritis, KneeArmsPeri-articular tranexamic acid, Intravenous tranexamic acid
NCT03074994 phase2unknown statusnot on this map

The Comparative Efficacy of Peri-articular and Intraarticular Tranexamic Acid in Total Knee Arthroplasty: A Prospective, Double-Blind Randomized, Controlled Trial

TypeinterventionalSponsorThammasat UniversityRan2016 to 2019Enrolled108ConditionsOsteoarthritis,KneeArmsPeri-articular TXA (15 mg/kg), Intraarticular TXA 2 g (40 mL), TXA combined with multimodal local anesthetic infiltration inject into peri-articular area, TXA 40 mL inject into intraaricular knee capsule
3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 6 syntheses or guidelines pooled it, 52 citations in OpenAlex.

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  15. [Early efficacy of local tranexamic acid in reducing postoperative swelling in hallux valgus surgery].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

P PinsornsakDepartment of Orthopaedic Surgery, Thammasat University, 99 Moo 18, Khlong Nueng, Khlong Luang, Pathumthani, Thailand, 12120. pinpiya2003@yahoo.com.
S RojanavijitkulDepartment of Orthopaedic Surgery, Thammasat University, 99 Moo 18, Khlong Nueng, Khlong Luang, Pathumthani, Thailand, 12120.
S ChumchuenDepartment of Orthopaedic Surgery, Thammasat University, 99 Moo 18, Khlong Nueng, Khlong Luang, Pathumthani, Thailand, 12120.
Thammasat University · TH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIntravenous tranexamic acid (IV TXA) is one of the most effective agents in use for reducing blood loss following total knee arthroplasty (TKA) but its safety regarding venous thromboembolic events (VTEs) remains in question. The direct, local application of TXA may reduce systemic toxicity whilst maintaining good or better bleeding control compared to IV TXA. The topical application of TXA via Hemovac drains has been reported previously with good results. However, there are no data on peri-articular TXA injections during TKA.

methodsWe conducted an open randomized, pilot study of peri-articular vs. IV TXA in 60 patients undergoing TKA. 30 patients received either: (i) 750 mg peri-articular TXA into the medial, lateral capsules and the quadriceps tendon prior to capsular closure and tourniquet deflation (group1), or (ii) 750 mg of IV TXA just before tourniquet deflation. Blood loss in the hemovac drain and hemoglobin (Hb) concentrations were measured at 24 and 48 h (h), and the number of blood transfusions and leg circumference measurements were recorded.

resultsAt 48 h, the total blood loss in the hemovac drain was 445 mL in group 1 vs. 520 mL in group 2 (p = 0.081) and the corresponding declines in Hb were 1.85 g/dL vs. 1.87 g/dL (p = 0.84). 16 patients received blood transfusions: 9 vs. 7 in groups 1 and 2, respectively (p = 0.928). There were no differences in thigh and lower leg circumferences, pain scores, knee flexion at discharge date and lengths of hospital stay. There were no clinically detected venous thromboembolic events.

conclusionThis pilot study has shown promising results for peri-articular TXA during TKA. Additional, larger studies are needed to confirm our results and be powered to show differences in efficacy and safety of peri-articular vs. IV TXA.

trial registrationClinicalTrials.gov Identifier NCT02829346 . Retrospectively registered: 07/11/2016.

Indexed as

Administration, IntravenousAgedAntifibrinolytic AgentsArthroplasty, Replacement, KneeBlood TransfusionFemaleHemoglobinsHumansInjections, Intra-ArticularLength of StayMaleMiddle AgedOsteoarthritis, KneePain MeasurementPilot ProjectsPostoperative HemorrhageAntifibrinolytic AgentsHemoglobinsTranexamic AcidBlood lossPeri-articular injectionTotal knee arthroplastyTranexamic acid

Identifiers

PMID27455842
PMCPMC4960744
OpenAlexW2500513307

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.