Evidence map›Paper›PMID 27455426›Full record

ArticleJournal of biophotonics2017

A compact fiber-optic probe-based singlet oxygen luminescence detection system.

Nathan R Gemmell, Aongus McCarthy, Michele M Kim, Israel Veilleux, Timothy C Zhu, Gerald S Buller, Brian C Wilson, Robert H Hadfield

Open access · hybridAbstract read
In one paragraph

Article in Journal of biophotonics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Singlet Oxygen in Photodynamic Therapy.Pharmaceuticals (Basel, Switzerland) · 2024
    Review
  7. Review
  8. Photochemistry and photobiology · 2017
    Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 3 countries.

Nathan R GemmellDivision of Electronic and Nanoscale Engineering, University of Glasgow, UK.
Aongus McCarthyInstitute of Photonics and Quantum Sciences, Heriot-Watt University, Edinburgh, EH14 4AS, UK.
Michele M KimDepartment of Radiation Oncology, University of Pennsylvania, USA.
Israel VeilleuxUniversity Health Network/University of Toronto, Canada.
Timothy C ZhuDepartment of Radiation Oncology, University of Pennsylvania, USA.
Gerald S BullerInstitute of Photonics and Quantum Sciences, Heriot-Watt University, Edinburgh, EH14 4AS, UK.
Brian C WilsonUniversity Health Network/University of Toronto, Canada.
Robert H HadfieldDivision of Electronic and Nanoscale Engineering, University of Glasgow, UK.
Heriot-Watt University · GBUniversity of Pennsylvania · USNanoScale Corporation (United States) · USUniversity Health Network · CAUniversity of Glasgow · GBUniversity of Toronto · CA

Funding

TUMOR HYPOXIA, PHOTOSENSITIZER, VASCULARITY AND PDTP01CA087971 · NCI · UNIVERSITY OF PENNSYLVANIA · PI BUSCH, THERESA M, CENGEL, KEITH A · 2001 to 2019
$24.8M
Image-guided treatment planning for pleural Photodynamic TherapyR01CA154562 · NCI · UNIVERSITY OF PENNSYLVANIA · PI ZHU, TIMOTHY C. · 2012 to 2016
$1.6M
NCI NIH HHS P01 CA087971NCI NIH HHS R01 CA154562
6 · The paper itself

Abstract

This paper presents a novel compact fiberoptic based singlet oxygen near-infrared luminescence probe coupled to an InGaAs/InP single photon avalanche diode (SPAD) detector. Patterned time gating of the single-photon detector is used to limit unwanted dark counts and eliminate the strong photosensitizer luminescence background. Singlet oxygen luminescence detection at 1270 nm is confirmed through spectral filtering and lifetime fitting for Rose Bengal in water, and Photofrin in methanol as model photosensitizers. The overall performance, measured by the signal-to-noise ratio, improves by a factor of 50 over a previous system that used a fiberoptic-coupled superconducting nanowire single-photon detector. The effect of adding light scattering to the photosensitizer is also examined as a first step towards applications in tissue in vivo.

Indexed as

Fiber Optic TechnologyLuminescencePhotosensitizing AgentsSignal-To-Noise RatioSinglet OxygenPhotosensitizing AgentsSinglet Oxygenfluorescencephoton countingquantum opticssinglet oxygen

Identifiers

PMID27455426
PMCPMC5266677
OpenAlexW2491914611

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.