ArticleMagnetic resonance in medicine2017
Diffusion tensor imaging of articular cartilage at 3T correlates with histology and biomechanics in a mechanical injury model.
Article in Magnetic resonance in medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 24 citations in OpenAlex.
- Diffusion Tensor Imaging of Knee Cartilage for Detection of Early Osteoarthritis and Prediction of Radiographic Progression.Journal of magnetic resonance imaging : JMRI · 2026Article
- Advances in cartilage imaging techniques.Nature reviews. Rheumatology · 2026Review
- Assessment of morphology, radiopacity gradient and mechanical properties of articular cartilage with contrast-enhanced high-resolution peripheral quantitative computed tomography.Frontiers in bioengineering and biotechnology · 2026Article
- Simultaneous multi-slice technique for reducing acquisition times in diffusion tensor imaging of the knee: a feasibility study.Skeletal radiology · 2025Article
- Review
- Assessment of Mechanically Induced Changes in Helical Fiber Microstructure Using Diffusion Tensor Imaging.Annals of biomedical engineering · 2024Article
- Validating the accuracy of multispectral metal artifact suppressed diffusion-weighted imaging.Medical physics · 2022Article
- The Mechanism and Role of ADAMTS Protein Family in Osteoarthritis.Biomolecules · 2022Review
- Article
- AnFrontiers in bioengineering and biotechnology · 2021Article
- Accuracy of collagen fibre estimation under noise using directional MR imaging.Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society · 2020Article
- Use of Computational Modeling to Study Joint Degeneration: A Review.Frontiers in bioengineering and biotechnology · 2020Review
- Osteoarthritis year in review 2018: mechanics.Osteoarthritis and cartilage · 2019Review
- A robust diffusion tensor model for clinical applications of MRI to cartilage.Magnetic resonance in medicine · 2018Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
purposeWe establish a mechanical injury model for articular cartilage to assess the sensitivity of diffusion tensor imaging (DTI) in detecting cartilage damage early in time. Mechanical injury provides a more realistic model of cartilage degradation compared with commonly used enzymatic degradation.
methodsNine cartilage-on-bone samples were obtained from patients undergoing knee replacement. The 3 Tesla DTI (0.18 × 0.18 × 1 mm
resultsAfter severe injury the mean diffusivity increased after 1 and 2 weeks, whereas the fractional anisotropy decreased after 2 weeks (P < 0.05). The QLV-parameters and OARSI grades of the severe injury group differed from the baseline with statistical significance. The changes in mean diffusivity across all the samples correlated with the changes in the OARSI grade (r = 0.72) and QLV-parameters (r = -0.75).
conclusionDTI is sensitive in tracking early changes after mechanical injury, and its changes correlate with changes in biomechanics and histology. Magn Reson Med 78:69-78, 2017. © 2016 International Society for Magnetic Resonance in Medicine.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.