Evidence map›Paper›PMID 27455317›Full record

ReviewNutrients2016

Potassium Intake, Bioavailability, Hypertension, and Glucose Control.

Michael S Stone, Lisa Martyn, Connie M Weaver

Open access · goldAbstract readReview
In one paragraph

Review in Nutrients, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 98 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
98citing papers in PubMed, 5 pooled it
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

98 citing papers in PubMed, 5 syntheses or guidelines pooled it, 292 citations in OpenAlex.

  1. Pooled it
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  9. Tissue-Specific Metabolite Profiling and Antioxidant Potential ofInternational journal of molecular sciences · 2026
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  14. Elevated NaInternational journal of molecular sciences · 2026
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38 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Michael S StoneDepartment of Nutrition Science, College of Health and Human Sciences, Purdue University, West Lafayette, IN 47907, USA. stone59@purdue.edu.
Lisa MartynDepartment of Nutrition Science, College of Health and Human Sciences, Purdue University, West Lafayette, IN 47907, USA. lmartyn@tcd.ie.
Connie M WeaverDepartment of Nutrition Science, College of Health and Human Sciences, Purdue University, West Lafayette, IN 47907, USA. weavercm@purdue.edu.
Purdue University West Lafayette · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Potassium is an essential nutrient. It is the most abundant cation in intracellular fluid where it plays a key role in maintaining cell function. The gradient of potassium across the cell membrane determines cellular membrane potential, which is maintained in large part by the ubiquitous ion channel the sodium-potassium (Na+-K+) ATPase pump. Approximately 90% of potassium consumed (60-100 mEq) is lost in the urine, with the other 10% excreted in the stool, and a very small amount lost in sweat. Little is known about the bioavailability of potassium, especially from dietary sources. Less is understood on how bioavailability may affect health outcomes. Hypertension (HTN) is the leading cause of cardiovascular disease (CVD) and a major financial burden ($50.6 billion) to the US public health system, and has a significant impact on all-cause morbidity and mortality worldwide. The relationship between increased potassium supplementation and a decrease in HTN is relatively well understood, but the effect of increased potassium intake from dietary sources on blood pressure overall is less clear. In addition, treatment options for hypertensive individuals (e.g., thiazide diuretics) may further compound chronic disease risk via impairments in potassium utilization and glucose control. Understanding potassium bioavailability from various sources may help to reveal how specific compounds and tissues influence potassium movement, and further the understanding of its role in health.

Indexed as

Evidence-Based MedicineGlobal HealthModels, BiologicalCardiovascular DiseasesDiabetes Mellitus, Type 2Dietary SupplementsGlucose IntoleranceHumansHypertensionIntestinal AbsorptionKidneyPotassiumPotassium DeficiencyPotassium, DietaryRenal EliminationRenal ReabsorptionPotassiumPotassium, Dietarybioavailabilitydiabetesglucose controlhypertensionpotassium

Identifiers

PMID27455317
PMCPMC4963920
OpenAlexW2498305212

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.