ArticleInternational journal of molecular sciences2016
Protective Effect of Salicornia europaea Extracts on High Salt Intake-Induced Vascular Dysfunction and Hypertension.
Article in International journal of molecular sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 47 citations in OpenAlex.
- Evaluating the Clinical Impact of a Polyphenol-Rich Extract fromNutrients · 2024Trial
- Assessing Sarcocornia as a Salt Substitute: Effects on Lipid Profile and Gelatinase Activity.Nutrients · 2024Trial
- Review
- Exploitation of ApulianMolecules (Basel, Switzerland) · 2025Article
- Phenolic Compounds inMolecules (Basel, Switzerland) · 2023Review
- Safety and efficacy of oil palm phenolic supplementation in improving lipid profile among hyperlipidemic adults: a phase 2, randomized, double-blind, placebo-controlled clinical trial.Frontiers in pharmacology · 2023Article
- Diet Supplementation with Polyphenol-RichNutrients · 2022Article
- Overview of the Polyphenols in Salicornia: From Recovery to Health-Promoting Effect.Molecules (Basel, Switzerland) · 2022Review
- Randomized Pilot Study on the Effects of Sarcocornia as a Salt Substitute in Arterial Blood Pressure and Vascular Function in Healthy Young Adults.Foods (Basel, Switzerland) · 2022Article
- From Biomedical Applications of Alginate towards CVD Implications Linked to COVID-19.Pharmaceuticals (Basel, Switzerland) · 2022Review
- Bioactive Compounds inPlants (Basel, Switzerland) · 2021Article
- Microparticles-Mediated Vascular Inflammation and its Amelioration by Antioxidant Activity of Baicalin.Antioxidants (Basel, Switzerland) · 2020Article
- Targeting Evolutionary Conserved Oxidative Stress and Immunometabolic Pathways for the Treatment of Respiratory Infectious Diseases.Antioxidants & redox signaling · 2020Review
- The Great Healing Potential Hidden in Plant Preparations of Antioxidant Properties: A Return to Nature?Oxidative medicine and cellular longevity · 2020Review
- The Ameliorative Effects of the Ethyl Acetate Extract ofOxidative medicine and cellular longevity · 2019Article
- Desalted Salicornia europaea powder and its active constituent, trans-ferulic acid, exert anti-obesity effects by suppressing adipogenic-related factors.Pharmaceutical biology · 2018Article
- Vascular Protection by Ethanol Extract ofEvidence-based complementary and alternative medicine : eCAM · 2018Article
- YXQN Reduces Alzheimer's Disease-Like Pathology and Cognitive Decline in APPswePS1dE9 Transgenic Mice.Frontiers in aging neuroscience · 2017Article
- Reactive Oxygen Species: A Key Hallmark of Cardiovascular Disease.Advances in medicine · 2016Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
High salt intake causes and aggravates arterial hypertension and vascular dysfunction. We investigated the effect of Salicornia europaea extracts (SE) on vascular function and blood pressure. SE constituents were analyzed using high performance liquid chromatography, and SE's effect on vascular function was evaluated in isolated porcine coronary arteries. SE's vascular protective effect was also evaluated in vivo using normotensive and spontaneous hypertensive rats (SHRs). SE mainly contained sodium chloride (55.6%), 5-(hydroxymethyl)furfural, p-coumaric acid, and trans-ferulic acid. High sodium (160 mmol/L) induced vascular dysfunction; however, SE containing the same quantity of sodium did not cause vascular dysfunction. Among the compounds in SE, trans-ferulic acid accounts for the vascular protective effect. Normotensive rats fed a high-salt diet showed significantly increased systolic blood pressure (SBP), diastolic blood pressure (DBP), and mean arterial pressure (MAP), which decreased significantly in the SE-treated groups. In SHRs, high edible salt intake significantly increased SBP, DBP, and MAP, but SE intake was associated with a significantly lower MAP. Thus, SE did not induce vascular dysfunction, and trans-ferulic acid might be at least partly responsible for the vasoprotective effect of SE. Taken together, SE could be used as an alternative to purified salt to prevent and ameliorate hypertension.
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Registered trials
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