ArticlePediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies2016
Protocolized Treatment Is Associated With Decreased Organ Dysfunction in Pediatric Severe Sepsis.
Article in Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 1 of them a synthesis that pooled it.
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Who cites it
49 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Surviving sepsis campaign international guidelines for the management of septic shock and sepsis-associated organ dysfunction in children.Intensive care medicine · 2020Guideline
- A Validation Argument for a Simulation-Based Training Course Centered on Assessment, Recognition, and Early Management of Pediatric Sepsis.Simulation in healthcare : journal of the Society for Simulation in Healthcare · 2018Trial
- Clinical Outcomes for Emergency Department Presentations of Sepsis Managed on a Clinical Pathway: A Systematic Review and Meta-Analysis.Healthcare (Basel, Switzerland) · 2026Review
- Triage Temperature and Timeliness of Sepsis Interventions in a Pediatric Emergency Department.The western journal of emergency medicine · 2025Article
- Early clinical evaluation of a vendor developed pediatric artificial intelligence sepsis model in the emergency department.Journal of the American Medical Informatics Association : JAMIA · 2025Article
- A Quality Improvement Intervention for the Initial Care of Pediatric Septic Shock in a Resource-Limited Setting.Journal of pediatrics. Clinical practice · 2025Article
- Identification of distinct clinical profiles of sepsis risk in paediatric emergency department patients using Bayesian profile regression.BMJ paediatrics open · 2025Article
- Survey of Thai Physicians' Practice in Pediatric Septic Shock.Children (Basel, Switzerland) · 2024Article
- From Pediatric Sepsis Epidemiologic Data to Improved Clinical Outcomes.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2024Article
- Sociodemographic Factors are Associated with Care Delivery and Outcomes in Pediatric Severe Sepsis.Critical care explorations · 2024Article
- Deciphering the molecular classification of pediatric sepsis: integrating WGCNA and machine learning-based classification with immune signatures for the development of an advanced diagnostic model.Frontiers in genetics · 2024Article
- Organ dysfunction and mortality in preterm neonates with late-onset bloodstream infection.Pediatric research · 2023Article
- A sepsis trigger tool reduces time to antibiotic administration in the NICU.Journal of perinatology : official journal of the California Perinatal Association · 2023Article
- Article
- "These Are Our Kids": Qualitative Interviews With Clinical Leaders in General Emergency Departments on Motivations, Processes, and Guidelines in Pediatric Sepsis Care.Annals of emergency medicine · 2022Article
- Article
- Prevalence, Characteristics, and Determinants of Suboptimal Care in the Initial Management of Community-Onset Severe Bacterial Infections in Children.JAMA network open · 2022Article
- Medication and Fluid Management of Pediatric Sepsis and Septic Shock.Paediatric drugs · 2022Review
- Pediatric sepsis phenotypes for enhanced therapeutics: An application of clustering to electronic health records.Journal of the American College of Emergency Physicians open · 2022Article
- The Effect of Rapid Initiation Versus Delayed Initiation of Antibiotics in Pediatric Patients With Sepsis.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2022Article
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Authors and funding
9 authors.
Funding
Abstract
objectivesTo determine whether treatment with a protocolized sepsis guideline in the emergency department was associated with a lower burden of organ dysfunction by hospital day 2 compared to nonprotocolized usual care in pediatric patients with severe sepsis.
designRetrospective cohort study.
settingTertiary care children's hospital from January 1, 2012, to March 31, 2014. SUBJECTS: Patients older than 56 days old and younger than 18 years old with international consensus defined severe sepsis and who required PICU admission within 24 hours of emergency department arrival were included. MEASUREMENTS AND MAIN
resultsThe exposure was the use of a protocolized emergency department sepsis guideline. The primary outcome was complete resolution of organ dysfunction by hospital day 2. One hundred eighty nine subjects were identified during the study period. Of these, 121 (64%) were treated with the protocolized emergency department guideline and 68 were not. There were no significant differences between the groups in age, sex, race, number of comorbid conditions, emergency department triage level, or organ dysfunction on arrival to the emergency department. Patients treated with protocolized emergency department care were more likely to be free of organ dysfunction on hospital day 2 after controlling for sex, comorbid condition, indwelling central venous catheter, Pediatric Index of Mortality-2 score, and timing of antibiotics and IV fluids (adjusted odds ratio, 4.2; 95% CI, 1.7-10.4).
conclusionsUse of a protocolized emergency department sepsis guideline was independently associated with resolution of organ dysfunction by hospital day 2 compared to nonprotocolized usual care. These data indicate that morbidity outcomes in children can be improved with the use of protocolized care.
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