ArticlePloS one2016
Selective Factors Associated with the Evolution of Codon Usage in Natural Populations of Arboviruses.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 23 citations in OpenAlex.
- A Revised Classification of Vesicular Stomatitis Virus (VSV) Genotypes and Subtypes.Pathogens (Basel, Switzerland) · 2026Article
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- Predicting novel mosquito-associated viruses from metatranscriptomic dark matter.NAR genomics and bioinformatics · 2024Article
- A study on the codon usage bias of arenavirus common genes.Frontiers in microbiology · 2024Article
- Exploring the Molecular Basis of Vesicular Stomatitis Virus Pathogenesis in Swine: Insights from Expression Profiling of Primary Macrophages Infected with M51R Mutant Virus.Pathogens (Basel, Switzerland) · 2023Article
- Novel approaches for the rapid development of rationally designed arbovirus vaccines.One health (Amsterdam, Netherlands) · 2023Article
- Molecular Tracking of the Origin of Vesicular Stomatitis Outbreaks in 2004 and 2018, Ecuador.Veterinary sciences · 2023Article
- Misclassified: identification of zoonotic transition biomarker candidates for influenza A viruses using deep neural network.Frontiers in genetics · 2023Article
- The future of zoonotic risk prediction.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Article
- Pirahy virus: Identification of a new and potential emerging arbovirus in South Brazil.Virus evolution · 2021Article
- The Codon Usage Code for Cotranslational Folding of Viral Capsids.Genome biology and evolution · 2021Article
- Edging on Mutational Bias, Induced Natural Selection From Host and Natural Reservoirs Predominates Codon Usage Evolution in Hantaan Virus.Frontiers in microbiology · 2021Article
- Characterization of a Novel Mitovirus of the Sand FlyViruses · 2020Article
- A Single Amino Acid Substitution in the Matrix Protein (M51R) of Vesicular Stomatitis New Jersey Virus Impairs Replication in Cultured Porcine Macrophages and Results in Significant Attenuation in Pigs.Frontiers in microbiology · 2020Article
- Review
- Increased Virulence of an Epidemic Strain of Vesicular Stomatitis Virus Is Associated With Interference of the Innate Response in Pigs.Frontiers in microbiology · 2018Article
- Dinucleotide Composition in Animal RNA Viruses Is Shaped More by Virus Family than by Host Species.Journal of virology · 2017Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Arboviruses (arthropod borne viruses) have life cycles that include both vertebrate and invertebrate hosts with substantial differences in vector and host specificity between different viruses. Most arboviruses utilize RNA for their genetic material and are completely dependent on host tRNAs for their translation, suggesting that virus codon usage could be a target for selection. In the current study we analyzed the relative synonymous codon usage (RSCU) patterns of 26 arboviruses together with 25 vectors and hosts, including 8 vertebrates and 17 invertebrates. We used hierarchical cluster analysis (HCA) and principal component analysis (PCA) to identify trends in codon usage. HCA demonstrated that the RSCU of arboviruses reflects that of their natural hosts, but not that of dead-end hosts. Of the two major components identified by PCA, the first accounted for 62.1% of the total variance, and among the 59 codons analyzed in this study, the leucine codon CTG had the highest correlation with the first principal component, however isoleucine had the highest correlation during amino acid analysis. Nucleotide and dinucleotide composition were the variables that explained most of the total codon usage variance. The results suggest that the main factors driving the evolution of codon usage in arboviruses is based on the nucleotide and dinucleotide composition present in the host. Comparing codon usage of arboviruses and potential vector hosts can help identifying potential vectors for emerging arboviruses.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.