ArticleThe American journal of surgical pathology2016
Predictors of Outcome in the Phenotypic Spectrum of Polymorphous Low-grade Adenocarcinoma (PLGA) and Cribriform Adenocarcinoma of Salivary Gland (CASG): A Retrospective Study of 69 Patients.
Article in The American journal of surgical pathology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Immunohistochemical Profile of Polymorphous Adenocarcinoma of Minor Salivary Gland: A Systematic Review and Meta-Analysis.Head and neck pathology · 2022Pooled it
- Hedgehog Components Are Present in Polymorphous Adenocarcinoma of the Salivary Gland Regardless of PRKD1 Mutation and Tissue Invasion.Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology · 2025Article
- Comprehensive Clinicopathologic, Morphologic, and Molecular Evaluation and Outcomes in Polymorphous Adenocarcinoma Tumors With Applicability of a 2-Tiered Grading System.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2025Article
- Polymorphous adenocarcinoma: a review of the literature and presentation of a case in an uncommon anatomical area.Medicine and pharmacy reports · 2025Article
- Nodal Metastasis in Low Grade Salivary Gland Carcinoma: A Retrospective Analysis of Incidence, Histologic Spectrum and Outcome.Head and neck pathology · 2025Article
- Relative Frequency of Primary Salivary Gland Tumors: Multicenter Study of 796 Cases from Riyadh, Saudi Arabia.Medicina (Kaunas, Lithuania) · 2024Article
- Microsecretory adenocarcinoma of the hard palate: a case report and literature review.Diagnostic pathology · 2024Review
- Proceedings of the 2024 North American Society of Head and Neck Pathology Companion Meeting, Baltimore, MD, March 24, 2024: Navigating Ancillary Studies in Basaloid/Blue Salivary Tumors.Head and neck pathology · 2024Review
- Stereotactic radiosurgery for recurrent skull base polymorphous adenocarcinoma invading the cavernous sinus: illustrative case.Journal of neurosurgery. Case lessons · 2023Article
- Cribriform adenocarcinoma of the minor salivary glands: a case report.Journal of medical case reports · 2023Article
- Article
- Polymorphous Adenocarcinoma: High-Grade Transformation With Immunohistochemical Workup.Cureus · 2022Article
- Polymorphous adenocarcinoma of the submandibular gland.BMJ case reports · 2021Article
- Article
- Polymorphous Adenocarcinoma.Surgical pathology clinics · 2021Review
- Histologic Classification and Molecular Signature of Polymorphous Adenocarcinoma (PAC) and Cribriform Adenocarcinoma of Salivary Gland (CASG): An International Interobserver Study.The American journal of surgical pathology · 2020Article
- Historical Evolution of the Polymorphous Adenocarcinoma.Head and neck pathology · 2019Review
- Polymorphous adenocarcinoma of salivary glands.Oral oncology · 2019Article
- Genomic analysis of recurrences and high-grade forms of polymorphous adenocarcinoma.Histopathology · 2019Article
- Polymorphous adenocarcinoma of the salivary glands: reappraisal and update.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2018Review
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Abstract
Polymorphous low-grade adenocarcinoma (PLGA) shows histologic diversity with fascicular and targetoid features while cribriform adenocarcinoma of salivary gland (CASG) demonstrates predominant cribriform and solid patterns with glomeruloid appearance and optical clear nuclei. The current study is designed to identify pathologic features that may predict clinical outcome in 69 PLGA/CASG. Seven patients had recurrences or distant metastasis, including 3 local recurrences, 2 nodal metastases, and 2 distant metastases. The following histologic factors predicted disease-free survival on univariate analysis: tumor size, bone invasion, lymphovascular invasion, tumor necrosis, ≥10% papillary pattern, and ≥30% cribriform pattern. On multivariate analysis, 10% of papillary pattern and 30% cribriform pattern were independent prognostic factors of disease-free survival. Histologic classification of the 69 tumors (based on the prior reported definition of CASG) showed 21 CASGs (30%), 23 PLGAs (33%), and 22 (32%) with indeterminate features of PLGA and CASG. In addition, 3 (4%) tumors demonstrated a predominant papillary pattern (≥50%). Interestingly, not all CASGs were located in the minor salivary gland and 2 tumors were identified in the parotid. One patient died from her disease and she harbored a CASG with >30% cribriform pattern. In conclusion, tumor size, bone invasion, and lymphovascular invasion are significant parameters that can predict adverse clinical behaviors in PLGA/CASG on univariate analysis. Using the prior reported definition, an overlapping histology between PLGA and CASG was noted in over a third of the cases. Regardless of tumor subclassification, the percentage of cribriform and papillary patterns seems to be prognostically relevant and should be documented.
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