ArticleActa physiologica (Oxford, England)2017
High-salt diet induces outward remodelling of efferent arterioles in mice with reduced renal mass.
Article in Acta physiologica (Oxford, England), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed, 13 citations in OpenAlex.
- NaHCOHypertension (Dallas, Tex. : 1979) · 2019Article
- Salt-induced effects on microvascular function: A critical factor in hypertension mediated organ damage.Journal of clinical hypertension (Greenwich, Conn.) · 2019Review
- Fenofibrate improves vascular endothelial function and contractility in diabetic mice.Redox biology · 2019Article
- High-Salt Loading Downregulates Nrf2 Expression in a Sodium-Dependent Manner in Renal Collecting Duct Cells.Frontiers in physiology · 2019Article
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11 authors at 4 institutions in 2 countries.
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Abstract
aimThe glomerular filtration rate (GFR) falls progressively in chronic kidney disease (CKD) which is caused by a reduction in the number of functional nephrons. The dysfunctional nephron exhibits a lower glomerular capillary pressure that is induced by an unbalance between afferent and efferent arteriole. Therefore, we tested the hypothesis that oxidative stress induced by CKD differentially impairs the structure or function of efferent vs. afferent arterioles.
methodsC57BL/6 mice received sham operations (sham) or 5/6 nephrectomy (RRM) and three months of normal- or high-salt diet or tempol. GFR was assessed from the plasma inulin clearance, arteriolar remodelling from media/lumen area ratio, myogenic responses from changes in luminal diameter with increases in perfusion pressure and passive wall compliance from the wall stress/strain relationships.
resultsMice with RRM fed a high salt (vs. sham) had a lower GFR (553 ± 25 vs. 758 ± 36 μL min
conclusionA reduction in renal mass with a high-salt diet induces oxidative stress that leads to an outward eutrophic remodelling in efferent arterioles and reduced wall compliance in both afferent and efferent arterioles. This may contribute to the lower GFR in this model of CKD.
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