ReviewPigment cell & melanoma research2016
The impact of skin colour on human photobiological responses.
Review in Pigment cell & melanoma research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 103 citations in OpenAlex.
- Beyond Melanin: A Literature Review of Photoprotection Mechanisms and Gaps in Skin of Color.Cureus · 2026Review
- Keratin intermediate filaments mechanically position melanin pigments for genome photoprotection.Nature cell biology · 2026Article
- Mechanistic Insights into Flavonoids in Cosmetic Applications: Multifunctional Roles and Formulation Considerations.Clinical, cosmetic and investigational dermatology · 2026Review
- Effect of a Dihydroxyacetone-Based Camouflage Agent on Ultraviolet-Induced Erythema.Journal of cosmetic dermatology · 2025Article
- Beneficial health effects of ultraviolet radiation: expert review and conference report.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2025Review
- Microbiome and Postbiotics in Skin Health.Biomedicines · 2025Review
- A Comprehensive Review of the Role of UV Radiation in Photoaging Processes Between Different Types of Skin.Cureus · 2025Review
- Expanding the application of tyrosine: engineering microbes for the production of tyrosine and its derivatives.Frontiers in bioengineering and biotechnology · 2025Review
- Squamous Cell Carcinoma: A Clinical and Histopathological Review of a South African Tertiary Dermatology Unit.Journal of skin cancer · 2025Article
- Expert Consensus on Big Data Collection of Skin and Appendage Disease Phenotypes in Chinese.Phenomics (Cham, Switzerland) · 2024Review
- Distinct cAMP Signaling Microdomains Differentially Regulate Melanosomal pH and Pigmentation.The Journal of investigative dermatology · 2023Article
- FermentedMolecules (Basel, Switzerland) · 2023Article
- Recent Advances and Progress on Melanin: From Source to Application.International journal of molecular sciences · 2023Review
- Skin cancer risk factors among Black South Africans-The Johannesburg Cancer Study, 1995-2016.Immunity, inflammation and disease · 2022Article
- A revised action spectrum for vitamin D synthesis by suberythemal UV radiation exposure in humans in vivo.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- The evolution of human skin pigmentation involved the interactions of genetic, environmental, and cultural variables.Pigment cell & melanoma research · 2021Review
- Pharmacologic manipulation of skin pigmentation.Pigment cell & melanoma research · 2021Review
- Physical Determinants of Vitamin D Photosynthesis: A Review.JBMR plus · 2021Article
- An Immunometabolic Shift Modulates Cytotoxic Lymphocyte Activation During Melanoma Progression in TRPA1 Channel Null Mice.Frontiers in oncology · 2021Article
- Validity of the Fitzpatrick Skin Phototype Classification in Ecuador.Advances in skin & wound care · 2020Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Terrestrial solar ultraviolet radiation (UVR) exerts both beneficial and adverse effects on human skin. Epidemiological studies show a lower incidence of skin cancer in people with pigmented skins compared to fair skins. This is attributed to photoprotection by epidermal melanin, as is the poorer vitamin D status of those with darker skins. We summarize a wide range of photobiological responses across different skin colours including DNA damage and immunosuppression. Some studies show the generally modest photoprotective properties of melanin, but others show little or no effect. DNA photodamage initiates non-melanoma skin cancer and is reduced by a factor of about 3 in pigmented skin compared with white skin. This suggests that if such a modest reduction in DNA damage can result in the significantly lower skin cancer incidence in black skin, the use of sunscreen protection might be extremely beneficial for susceptible population. Many contradictory results may be explained by protocol differences, including differences in UVR spectra and exposure protocols. We recommend that skin type comparisons be done with solar-simulated radiation and standard erythema doses or physical doses (J/m
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.