Observational studyJournal of computer assisted tomography
Baseline Cartilage Thickness and Meniscus Extrusion Predict Longitudinal Cartilage Loss by Quantitative Magnetic Resonance Imaging: Data From the Osteoarthritis Initiative.
Observational study in Journal of computer assisted tomography. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed.
- Weight bearing 3-D joint space width distribution at the knee varies according to location and extent of meniscal extrusion: A MOST investigation.Osteoarthritis imaging · 2024Article
- Assessment of meniscal extrusion with ultrasonography: a systematic review and meta-analysis.Knee surgery & related research · 2024Article
- Weight bearing 3-D joint space width distribution at the knee varies according to location and extent of meniscal extrusion: A MOST investigation.Osteoarthritis imaging · 2023Article
- Determining a Threshold of Medial Meniscal Extrusion for Prediction of Knee Pain and Cartilage Damage Progression Over 4 Years: Data From the Osteoarthritis Initiative.AJR. American journal of roentgenology · 2021Article
- Association Between Declining Walking Speed and Increasing Bone Marrow Lesion and Effusion Volume in Individuals with Accelerated Knee Osteoarthritis.Arthritis care & research · 2019Article
- Article
- Society of Skeletal Radiology 2015 annual meeting summary.Skeletal radiology · 2016Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
objectiveThis study aimed to assess how meniscus damage and baseline cartilage thickness influence the rate of cartilage loss and knee pain.
methodsOf 4796 participants in the Osteoarthritis Initiative, 86 had baseline and 48-month follow-up quantitative magnetic resonance imaging data for medial compartment cartilage thickness. Baseline meniscus pathology was scored by a musculoskeletal radiologist using Whole-Organ Magnetic Resonance Imaging Score. Findings were correlated with 72-month Knee injury and Osteoarthritis Outcome Score.
resultsUnivariate analysis showed cartilage change was not influenced by demographic variables. Multivariable regression revealed that initial cartilage thickness (-1.07 mm at 48 months for every 1 mm decrease at baseline, P < 0.001) and meniscus extrusion (-0.33 mm if present at baseline, P < 0.001) were the strongest predictors of medial compartment cartilage thickness at 48 months. Knee injury and Osteoarthritis Outcome Score pain scores did not correlate with cartilage loss.
conclusionsBaseline cartilage thickness and meniscus extrusion are important and independent predictors for accelerated cartilage loss. However, the degree of cartilage loss did not correlate with midterm change in clinical outcome scores.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.