ReviewExperimental and clinical psychopharmacology2016
Human drug discrimination: A primer and methodological review.
Review in Experimental and clinical psychopharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- Switching from menthol to non-menthol cigarettes does not impact acute responses to intravenous nicotine.Pharmacology, biochemistry, and behavior · 2025Trial
- Semaglutide, tirzepatide, and retatrutide attenuate the interoceptive effects of alcohol in male and female rats.Psychopharmacology · 2026Article
- Pulsed nicotine infusions as a model for smoking: validating a tool to explore nicotine thresholds in humans.Psychopharmacology · 2024Article
- Stimulus mediation, specificity and impact of menthol in rats trained to discriminate puffs of nicotine e-cigarette aerosol from nicotine-free aerosol.Psychopharmacology · 2024Article
- Translational In Vivo Assays in Behavioral Biology.Annual review of pharmacology and toxicology · 2024Review
- Abuse potential assessment of the dual orexin receptor antagonist daridorexant in rats.Journal of psychopharmacology (Oxford, England) · 2023Article
- Assessment of Abuse-Related Discriminative Stimulus Effects of Nicotine Aerosol in Rodents.The Journal of pharmacology and experimental therapeutics · 2023Article
- Predator odor (TMT) exposure potentiates interoceptive sensitivity to alcohol and increases GABAergic gene expression in the anterior insular cortex and nucleus accumbens in male rats.Alcohol (Fayetteville, N.Y.) · 2022Article
- A Brief Introduction to Human Behavioral Pharmacology: Methods, Design Considerations and Ethics.Perspectives on behavior science · 2022Article
- How to account for hallucinations in the interpretation of the antidepressant effects of psychedelics: a translational framework.Psychopharmacology · 2022Article
- Interoception and alcohol: Mechanisms, networks, and implications.Neuropharmacology · 2021Review
- Hypothalamic control of interoceptive hunger.Current biology : CB · 2021Article
- Serotonergic Facilitation of Forelimb Functional Recovery in Rats with Cervical Spinal Cord Injury.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2021Article
- Preliminary test of cigarette nicotine discrimination threshold in non-dependent versus dependent smokers.Drug and alcohol dependence · 2017Article
- Threshold dose for behavioral discrimination of cigarette nicotine content in menthol vs. non-menthol smokers.Psychopharmacology · 2017Article
- Drug Discrimination: Historical Origins, Important Concepts, and Principles.Current topics in behavioral neurosciencesReview
- Cross-Species Translational Findings in the Discriminative Stimulus Effects of Ethanol.Current topics in behavioral neurosciencesReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Drug-discrimination procedures empirically evaluate the control that internal drug states exert over behavior. They provide a highly selective method to investigate the neuropharmacological underpinnings of the interoceptive effects of drugs. Historically, drug discrimination has been one of the most widely used assays in the field of behavioral pharmacology. Drug-discrimination procedures have also been adapted for use with humans and are conceptually similar to preclinical drug-discrimination techniques in that a behavior is differentially reinforced contingent on the presence or absence of a specific interoceptive drug stimulus. This review gives some general history and background concerning the major theoretical concepts and principles of drug-discrimination research as well as its relevance to substance-use disorders. This article also provides a procedural overview and discusses key methodological issues that must be considered when designing and conducting a human drug-discrimination study. Although drug discrimination is unequivocally one of the most sophisticated and useful behavioral assays to investigate the underlying neuropharmacology of drugs in vivo, enthusiasm for its use has steadily declined in the last decade and a half. We conclude by commenting on the current state of drug-discrimination research and suggest potential avenues for future drug-discrimination research. (PsycINFO Database Record
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.