ArticleInvestigative ophthalmology & visual science2016
Structural Change Can Be Detected in Advanced-Glaucoma Eyes.
Article in Investigative ophthalmology & visual science, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00221897 (Diagnostic Innovations in Glaucoma Study), which is not on this map. Cited by 40 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Diagnostic Innovations in Glaucoma Study
Who cites it
40 citing papers in PubMed, 94 citations in OpenAlex.
- Estimating Optical Coherence Tomography Structural Measurement Floors to Improve Detection of Progression in Advanced Glaucoma.American journal of ophthalmology · 2017Trial
- Subtype-Specific Macular Vascular Signatures in Primary Open-Angle, Pseudoexfoliative, and Normal-Tension Glaucoma: OCT Angiography Study.Medicina (Kaunas, Lithuania) · 2026Article
- Number of macula optical coherence tomography scans needed to detect glaucoma progression.The British journal of ophthalmology · 2025Article
- Detecting glaucoma worsening using optical coherence tomography derived visual field estimates.Scientific reports · 2025Article
- Comparison of glaucoma progression rate in glaucoma patients at different stages using guided progression analysis with optical coherence tomography.BMC ophthalmology · 2025Article
- Detecting Visual Field Worsening From Optic Nerve Head and Macular Optical Coherence Tomography Thickness Measurements.Translational vision science & technology · 2024Article
- Values of macular ganglion cell-inner plexiform layer and 10-2 visual field measurements in detecting and evaluating glaucoma.International journal of ophthalmology · 2024Article
- Detecting disease progression in mild, moderate and severe glaucoma.Current opinion in ophthalmology · 2023Review
- The Association Between Regional Macula Vessel Density and Central Visual Field Damage in Advanced Glaucoma Eyes.Journal of glaucoma · 2022Article
- Progression detection capabilities of circumpapillary and macular vessel density in advanced glaucomatous eyes.Scientific reports · 2022Article
- Optical Microangiography and Progressive Ganglion Cell-Inner Plexiform Layer Loss in Primary Open-Angle Glaucoma.American journal of ophthalmology · 2022Article
- Proteome alterations in the aqueous humor reflect structural and functional phenotypes in patients with advanced normal-tension glaucoma.Scientific reports · 2022Article
- Prediction of Visual Field Progression from OCT Structural Measures in Moderate to Advanced Glaucoma.American journal of ophthalmology · 2021Article
- Long-term effects of trabeculectomy in primary open-angle glaucoma on segmented macular ganglion cell complex alterations.International ophthalmology · 2021Article
- Detection of Glaucoma Deterioration in the Macular Region with Optical Coherence Tomography: Challenges and Solutions.American journal of ophthalmology · 2021Review
- Investigation of associations between Piezo1 mechanoreceptor gain-of-function variants and glaucoma-related phenotypes in humans and mice.Scientific reports · 2020Article
- Comparison of Rates of Progression of Macular OCT Measures in Glaucoma.Translational vision science & technology · 2020Article
- Trends in the Retinal Nerve Fiber Layer Thickness Changes with Different Degrees of Visual Field Defects.Journal of ophthalmology · 2020Article
- Individual Macular Layer Evaluation with Spectral Domain Optical Coherence Tomography in Normal and Glaucomatous Eyes.Clinical ophthalmology (Auckland, N.Z.) · 2020Article
- Longitudinal Macular Structure-Function Relationships in Glaucoma and Their Sources of Variability.American journal of ophthalmology · 2019Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo compare spectral-domain optical coherence tomography (SD-OCT) standard structural measures and a new three-dimensional (3D) volume optic nerve head (ONH) change detection method for detecting change over time in severely advanced-glaucoma (open-angle glaucoma [OAG]) patients.
methodsThirty-five eyes of 35 patients with very advanced glaucoma (defined as a visual field mean deviation < -21 dB) and 46 eyes of 30 healthy subjects to estimate aging changes were included. Circumpapillary retinal fiber layer thickness (cpRNFL), minimum rim width (MRW), and macular retinal ganglion cell-inner plexiform layer (GCIPL) thicknesses were measured using the San Diego Automated Layer Segmentation Algorithm (SALSA). Progression was defined as structural loss faster than 95th percentile of healthy eyes. Three-dimensional volume ONH change was estimated using the Bayesian-kernel detection scheme (BKDS), which does not require extensive retinal layer segmentation.
resultsThe number of progressing glaucoma eyes identified was highest for 3D volume BKDS (13, 37%), followed by GCPIL (11, 31%), cpRNFL (4, 11%), and MRW (2, 6%). In advanced-OAG eyes, only the mean rate of GCIPL change reached statistical significance, -0.18 μm/y (P = 0.02); the mean rates of cpRNFL and MRW change were not statistically different from zero. In healthy eyes, the mean rates of cpRNFL, MRW, and GCIPL change were significantly different from zero. (all P < 0.001).
conclusionsGanglion cell-inner plexiform layer and 3D volume BKDS show promise for identifying change in severely advanced glaucoma. These results suggest that structural change can be detected in very advanced disease. Longer follow-up is needed to determine whether changes identified are false positives or true progression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.