ArticleInvestigative ophthalmology & visual science2016
In Vivo Imaging of Corneal Endothelial Dystrophy in Boston Terriers: A Spontaneous, Canine Model for Fuchs' Endothelial Corneal Dystrophy.
Article in Investigative ophthalmology & visual science, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 41 citations in OpenAlex.
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- Comparison of Corneal Endothelial Imaging Techniques by Specular Microscopy in Unsedated Healthy Dogs.Veterinary ophthalmology · 2026Article
- Pluripotent Stem Cell-Derived Corneal Endothelial Cells Form a Functional Corneal Endothelium in Canines.Translational vision science & technology · 2025Article
- Diagnostic Ophthalmology.The Canadian veterinary journal = La revue veterinaire canadienne · 2025Article
- Canine corneal endothelial cell analysis using vital dyes and light microscopy.Veterinary ophthalmology · 2025Article
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- Topical netarsudil for the treatment of primary corneal endothelial degeneration in dogs.Scientific reports · 2024Article
- Squishy matters - Corneal mechanobiology in health and disease.Progress in retinal and eye research · 2024Review
- Canine Descemet Stripping Endothelial Keratoplasty with a Tissue Insertion Device: Technique and Long-Term Outcome.Case reports in veterinary medicine · 2023Article
- Topical Ripasudil for the Treatment of Primary Corneal Endothelial Degeneration in Dogs.Translational vision science & technology · 2022Article
- Canine endotheliitis: Clinical characteristics, advanced imaging features, and treatment.Veterinary ophthalmology · 2022Article
- Multimodal ocular imaging of known and novel corneal stromal disorders in dogs.BMC veterinary research · 2022Article
- Animal models of corneal endothelial dysfunction to facilitate development of novel therapies.Annals of translational medicine · 2021Review
- Comparison of automated vs manual analysis of corneal endothelial cell density and morphology in normal and corneal endothelial dystrophy-affected dogs.Veterinary ophthalmology · 2020Article
- Article
- Effects of 5% sodium chloride ophthalmic ointment on thickness and morphology of the normal canine cornea.Veterinary ophthalmology · 2019Article
- Article
- Comparison of ultrasonic pachymetry and Fourier-domain optical coherence tomography for measurement of corneal thickness in dogs with and without corneal disease.Veterinary journal (London, England : 1997) · 2018Article
- Assessment of Outer Retinal Remodeling in the Hibernating 13-Lined Ground Squirrel.Investigative ophthalmology & visual science · 2018Article
- Latrunculin B and substratum stiffness regulate corneal fibroblast to myofibroblast transformation.Experimental eye research · 2018Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
purposeBoston Terriers (BTs) have a greater prevalence of corneal endothelial dystrophy (CED), in comparison to other canine breeds. Similar to Fuchs' endothelial corneal dystrophy (FECD), this condition is characterized by endothelial cell degeneration with secondary corneal edema. This study assessed corneal morphology using in vivo confocal microscopy (IVCM) and Fourier-domain optical coherence tomography (FD-OCT) in BTs with and without CED.
methodsThe corneas of 16 BTs with CED and 15 unaffected, age-matched BTs underwent clinical evaluation and were imaged using IVCM and FD-OCT. A two-sample t-test or Mann-Whitney rank sum test were used to statistically compare parameters between groups. Data are presented as mean ± SD or median (range).
resultsMean age did not significantly differ between affected and unaffected dogs at 10.0 ± 2.0 and 10.6 ± 2.4 years, respectively (P = 0.437). Females (69%) were overrepresented among the CED-affected dogs. In CED patients, IVCM demonstrated endothelial polymegathism and pleomorphism. Corneal endothelial density was significantly less (P < 0.001) in dogs with CED (1026 ± 260 cells/mm2) versus age-matched controls (2297 ± 372 cells/mm2). Fourier-domain OCT demonstrated a significant increase (P < 0.01) in central corneal and endothelium-Descemet's complex thickness in dogs with CED versus age-matched controls at 1019 (485-1550) or 536 (464-650) μm and 32 (22-56) or 25 (15-34) μm, respectively.
conclusionsCorneal endothelial dystrophy in BTs is a bilateral, adult-onset condition that shares many similarities with FECD. Thus, CED could serve as a spontaneous disease model to study the pathogenesis of and develop novel treatments for FECD.
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