Evidence map›Paper›PMID 27454553›Full record

ArticleTopics in stroke rehabilitation2017

Ventilatory threshold may be a more specific measure of aerobic capacity than peak oxygen consumption rate in persons with stroke.

Pierce Boyne, Darcy Reisman, Michael Brian, Brian Barney, Ava Franke, Daniel Carl, Jane Khoury, Kari Dunning

Registry-linked trialAbstract read
In one paragraph

Article in Topics in stroke rehabilitation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04042961 (Effect of Reactive Balance Training on Physical Fitness Post-stroke), which is not on this map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04042961 naterminatednot on this mapstarted 2019, after this paper: background citation

Effect of Reactive Balance Training on Physical Fitness Post-stroke

TypeinterventionalSponsorToronto Rehabilitation InstituteRan2019 to 2025Enrolled28ConditionsCVA (Cerebrovascular Accident)ArmsReactive balance training, Aerobic and strength training (AST)
3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Pierce Boynea Department of Rehabilitation Sciences , College of Allied Health Sciences, University of Cincinnati , Cincinnati , OH , USA.
Darcy Reismanc Department of Physical Therapy , College of Health Sciences, University of Delaware , Newark , DE , USA.
Michael Brianc Department of Physical Therapy , College of Health Sciences, University of Delaware , Newark , DE , USA.
Brian Barneya Department of Rehabilitation Sciences , College of Allied Health Sciences, University of Cincinnati , Cincinnati , OH , USA.
Ava Frankea Department of Rehabilitation Sciences , College of Allied Health Sciences, University of Cincinnati , Cincinnati , OH , USA.
Daniel Carla Department of Rehabilitation Sciences , College of Allied Health Sciences, University of Cincinnati , Cincinnati , OH , USA.
Jane Khouryb Department of Environmental Health , College of Medicine, University of Cincinnati , Cincinnati , OH , USA.
Kari Dunninga Department of Rehabilitation Sciences , College of Allied Health Sciences, University of Cincinnati , Cincinnati , OH , USA.

Funding

Cincinnati Center for Clinical and Translational Sciences and TrainingUL1TR000077 · NCATS · UNIVERSITY OF CINCINNATI · PI HEUBI, JAMES E., TSEVAT, JOEL · 2012 to 2014
$9.9M
KL2 Training ProgramKL2TR001426 · NCATS · UNIVERSITY OF CINCINNATI · PI ZELLER, MARGARET H · 2015 to 2024
$6.8M
INTERVENTIONS TO IMPROVE PHYSICAL ACTIVITY AFTER STROKER21HD071042 · NICHD · UNIVERSITY OF DELAWARE · PI REISMAN, DARCY S. · 2012 to 2013
$411k
NCATS NIH HHS UL1 TR000077NICHD NIH HHS R21 HD071042
6 · The paper itself

Abstract

backgroundAfter stroke, aerobic deconditioning can have a profound impact on daily activities. This is usually measured by the peak oxygen consumption rate achieved during exercise testing (VO2-peak). However, VO2-peak may be distorted by motor function. The oxygen uptake efficiency slope (OUES) and VO2 at the ventilatory threshold (VO2-VT) could more specifically assess aerobic capacity after stroke, but this has not been tested.

objectivesTo assess the differential influence of motor function on three measures of aerobic capacity (VO2-peak, OUES, and VO2-VT) and to evaluate the inter-rater reliability of VO2-VT determination post-stroke.

methodsAmong 59 persons with chronic stroke, cross-sectional correlations with motor function (comfortable gait speed [CGS] and lower extremity Fugl-Meyer [LEFM]) were compared between the different aerobic capacity measures, after adjustment for covariates, in order to isolate any distorting effect of motor function. Reliability of VO2-VT determination between three raters was assessed with intra-class correlation (ICC).

resultsCGS was moderately correlated with VO2-peak (r = 0.52, p < 0.0001) and weakly correlated with OUES (r = 0.41, p = 0.002) and VO2-VT (r = 0.37, p = 0.01). LEFM was weakly correlated with VO2-peak (r = 0.26, p = 0.055) and very weakly correlated with OUES (r = 0.19, p = 0.17) and VO2-VT (r = 0.14, p = 0.31). Compared to VO2-peak, VO2-VT was significantly less correlated with CGS (r difference = -0.16, p = 0.02). Inter-rater reliability of VO2-VT determination was high (ICC: 0.93, 95% CI: 0.89-0.96).

conclusionsMotor dysfunction appears to artificially lower measured aerobic capacity. VO2-VT seemed to be less distorted than VO2-peak and had good inter-rater reliability, so it may provide more specific assessment of aerobic capacity post-stroke.

Indexed as

ExerciseAgedCross-Sectional StudiesFemaleHumansMaleMiddle AgedMovement DisordersOxygen ConsumptionReproducibility of ResultsSeverity of Illness IndexStatistics as TopicStrokeStroke RehabilitationAerobic capacityDeconditioningExercise testingMotor functionParesisStroke

Identifiers

PMID27454553
PMCPMC5588902

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.