ArticlePain2016
Genome-wide association analysis of pain severity in dysmenorrhea identifies association at chromosome 1p13.2, near the nerve growth factor locus.
Article in Pain, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 4 syntheses or guidelines pooled it, 56 citations in OpenAlex.
- The genetics of primary dysmenorrhoea: a systematic review.Reproduction & fertility · 2026Pooled it
- The genetic basis of endometriosis and comorbidity with other pain and inflammatory conditions.Nature genetics · 2023Pooled it
- Japanese GWAS identifies variants for bust-size, dysmenorrhea, and menstrual fever that are eQTLs for relevant protein-coding or long non-coding RNAs.Scientific reports · 2018Pooled it
- Prevalence of dysmenorrhea and associated factors among students in Ethiopia: A systematic review and meta-analysis.Women's health (London, England)Pooled it
- Prevalence of Dysmenorrhea and Its Association With Dietary Habits Among Female Students of Mid-West University, Surkhet, Nepal: An Analytical Cross-Sectional Study.Health science reports · 2026Article
- Primary dysmenorrhea among female medical students at Haramaya university: a cross sectional study in Harar, Eastern Ethiopia.Scientific reports · 2025Article
- Dysmenorrhea and Adolescent Mental Health: A School-Based Cross-Sectional Study.BJOG : an international journal of obstetrics and gynaecology · 2025Article
- The prevalence and associated risk factors of primary dysmenorrhea among women in Beijing: a cross-sectional study.Scientific reports · 2025Article
- Natural History of Menstrual Pain and Associated Risk Factors in Early Adolescence.Journal of pediatric and adolescent gynecology · 2025Article
- Prevalence and risk factors of primary dysmenorrhoea among medical students: a cross-sectional survey in Indonesia.BMJ open · 2024Article
- Familial coaggregation and shared genetic influence between major depressive disorder and gynecological diseases.European journal of epidemiology · 2024Article
- Article
- Distribution of Brain-Derived Neurotrophic Factor in the Brain of the Small-Spotted CatsharkInternational journal of molecular sciences · 2023Article
- Assessment of prevalence, knowledge and health-related practices of dysmenorrhea among Malaysian women in Kuala Lumpur: a cross-sectional survey.Annals of medicine · 2023Article
- Disease Burden of Dysmenorrhea: Impact on Life Course Potential.International journal of women's health · 2023Review
- Primary dysmenorrhoea in adolescents and young women: A twin family study of maternal transmission, genetic influence and associations.The Australian & New Zealand journal of obstetrics & gynaecology · 2022Article
- Primary Dysmenorrhea: Pathophysiology, Diagnosis, and Treatment Updates.Korean journal of family medicine · 2022Article
- Prevalence of primary dysmenorrhea, its intensity, impact and associated factors among female students' at Gondar town preparatory school, Northwest Ethiopia.BMC women's health · 2020Article
- Dysmenorrhea and Associated Factors among Polish Women: A Cross-Sectional Study.Pain research & management · 2020Article
- Prevalence, Wellbeing, and Symptoms of Dysmenorrhea among University Nursing Students in Greece.Diseases (Basel, Switzerland) · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dysmenorrhea is a common chronic pelvic pain syndrome affecting women of childbearing potential. Family studies suggest that genetic background influences the severity of dysmenorrhea, but genetic predisposition and molecular mechanisms underlying dysmenorrhea are not understood. In this study, we conduct the first genome-wide association study to identify genetic factors associated with dysmenorrhea pain severity. A cohort of females of European descent (n = 11,891) aged 18 to 45 years rated their average dysmenorrhea pain severity. We used a linear regression model adjusting for age and body mass index, identifying one genome-wide significant (P < 5 × 10) association (rs7523086, P = 4.1 × 10, effect size 0.1 [95% confidence interval, 0.074-0.126]). This single nucleotide polymorphism is colocalising with NGF, encoding nerve growth factor. The presence of one risk allele corresponds to a predicted 0.1-point increase in pain intensity on a 4-point ordinal pain scale. The putative effects on NGF function and/or expression remain unknown. However, genetic variation colocalises with active epigenetic marks in fat and ovary tissues, and expression levels in aorta tissue of a noncoding RNA flanking NGF correlate. Participants reporting extreme dysmenorrhea pain were more likely to report being positive for endometriosis, polycystic ovarian syndrome, depression, and other psychiatric disorders. Our results indicate that dysmenorrhea pain severity is partly genetically determined. NGF already has an established role in chronic pain disorders, and our findings suggest that NGF may be an important mediator for gynaecological/pelvic pain in the viscera.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.