ArticleMolecular immunology2016
Regulation of SATB1 during thymocyte development by TCR signaling.
Article in Molecular immunology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 27 citations in OpenAlex.
- Enhanced anti-liver tumor efficacy of chimeric antigen receptor-T cells via SATB1 modulation.Cell death & disease · 2025Article
- Transcriptional regulator SATB1 limits CD8Nature immunology · 2025Article
- Developmental features and unique characteristics of peptide-specific PLZFNature communications · 2025Article
- Long Non-Coding RNA ANRIL Regulates Inflammatory Factor Expression in Ulcerative Colitis Via the miR-191-5p/SATB1 Axis.Inflammation · 2024Article
- Identification of a novel enhancer essential forLife science alliance · 2023Article
- CUT homeobox genes: transcriptional regulation of neuronal specification and beyond.Frontiers in cellular neuroscience · 2023Review
- SATB1 ensures appropriate transcriptional programs within naïve CD8Immunology and cell biology · 2022Article
- 3D Genome Organization as an Epigenetic Determinant of Transcription Regulation in T Cells.Frontiers in immunology · 2022Review
- SATB1-mediated chromatin landscape in T cells.Nucleus (Austin, Tex.) · 2020Review
- Dynamic regulation of chromatin organizer SATB1 via TCR-induced alternative promoter switch during T-cell development.Nucleic acids research · 2020Article
- SATB1 as oncogenic driver and potential therapeutic target in head & neck squamous cell carcinoma (HNSCC).Scientific reports · 2020Article
- Divergent SATB1 expression across human life span and tissue compartments.Immunology and cell biology · 2019Article
- Review
- Satb1 regulates the effector program of encephalitogenic tissue Th17 cells in chronic inflammation.Nature communications · 2019Article
- Decreased SATB1 expression promotes AML cell proliferation through NF-κB activation.Cancer cell international · 2019Article
- NF-κB Signaling and IL-4 Signaling Regulate SATB1 Expression via Alternative Promoter Usage During Th2 Differentiation.Frontiers in immunology · 2019Article
- Article
- Long noncoding RNA lncKdm2b: A critical player in the maintenance of group 3 innate lymphoid cells.Cellular & molecular immunology · 2018Article
- Expression and clinical significance of SATB1 and TLR4 in breast cancer.Oncology letters · 2017Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
T lymphocyte development and differentiation is a multi-step process that begins in the thymus and completed in the periphery. Sequential development of thymocytes is dependent on T cell receptor (TCR) signaling and an array of transcription factors. In this study we show that special AT-rich binding protein 1 (SATB1), a T lineage-enriched chromatin organizer and regulator, is induced in response to TCR signaling during early thymocyte development. SATB1 expression profile coincides with T lineage commitment and upregulation of SATB1 correlates with positive selection of thymocytes. CD4 thymocytes exhibit a characteristic bimodal expression pattern that corresponds to immature and mature CD4 thymocytes. We also demonstrate that GATA3, the key transcriptional regulator of αβ T cells positively regulates SATB1 expression in thymocytes suggesting an important role for SATB1 during T cell development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.